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Homebuyers have greater influence in the housing market, particularly in the Sun Belt, as contract cancellations increase

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A surging wave of home-sale cancellations is tilting the balance in the housing market from sellers to buyers. In June 2025, nearly 15% of pending home sales fell through, per Redfin, a record high for June data stretching back to 2017. The contract cancellations are concentrated in the Sun Belt states like Florida and Texas that have powered housing since the pandemic housing boom. The consequences of contract cancellations reach beyond individual buyers and sellers to builders, agents, and the broader economy.

Just over 57,000 home-purchase agreements were canceled in June, Redfin found, which is nearly 15% of homes that went under contract that month. This cancellation rate is up from 13.9% the previous June. The trend is evident nationwide, but especially pronounced in Sun Belt cities including Jacksonville, Florida, Las Vegas, and Atlanta, which are recording cancellation rates near or above 20%. High interest rates, high insurance costs, and high property taxes have also affected cancellation rates, according to Cotality (formerly CoreLogic).

A buyers’ market or something else?

Some factors favoring buyers have improved. Inventory is up—Zillow finds 1.36 million homes on the market in June, the most since late 2019—while demand has softened. With more choices and less competition, buyers can afford to be more selective, with Zillow finding the share of listings with a price cut hitting 26.6% in June, the highest monthly mark in Zillow records dating back through 2018, and near the all-time high of 27% from September 2022. 

Sellers have also started yanking properties from the market that aren’t selling at a price they think is worth it; delistings skyrocketing 47% year-over-year in June, according to Realtor.com.

“What we’re seeing nationally is a market that’s gradually rebalancing, with buyers gaining leverage and sellers facing a tradeoff: Adjust to the market and sell for less, or hold out and risk sitting indefinitely,” Realtor.com Senior Economist Jake Krimmel previously told Fortune. “Many sellers still aren’t pricing to sell.”

Another difference from pandemic buying conditions is fewer buyers are waiving inspection and appraisal contingencies. Now they’re being used as opportunities to renegotiate or walk away if (and when) problems arise.

It’s not a full-blown buyers’ market, though, as anxiety over the broader economy has many would-be homeowners thinking twice. Several factors are contributing to financial jitters. Mortgage rates remain stubbornly high at around 6.8%, keeping monthly payments near historic peaks, the median national sale price is still at record highs, and buyer confidence is challenged by macro uncertainty related to tariffs, inflation, and fears of a potential recession. In fact, a recent LegalShield survey shows 70% of homeowners and prospective buyers worry a potential recession and tariffs could disrupt their housing plans.

Many discover the monthly payments, once fully calculated, are simply too much to bear and back out at the last minute. Others are hoping for prices—or rates—to drop soon and choose to wait it out. For the first time in years, realtors report buyers are negotiating harder. Sellers, for their part, are now more willing to make concessions, from price reductions to agreeing to costly repairs. This shifting balance is giving buyers more room to shop around and less incentive to stick with a deal if it’s anything less than perfect.

Headwinds in Florida and Texas

Florida and Texas, often the leaders in home sales during the last five years, are now leading in rates of cancellation. Several local factors are at play, from the influx of newly built homes increasing available inventory to soaring insurance premiums, especially in disaster-prone regions. These are a drag on the housing market generally and are playing into cancellations as some potential buyers are abandoning deals after receiving quotes.

Across the Sun Belt, inventory is tilting the playing field, with single-family home inventory up 32% year-over-year in some metros. In certain cities, the months’ supply of homes (inventory-to-sales ratio) has ballooned to nine to 12 months, well above the six-month threshold for a balanced market.

Florida had the largest number of homes for sale in the U.S. as of June 2025. Active listings have spiked, with Central Florida posting its highest home inventory levels in 15 years. This has pushed median home prices down about 2%–3% compared to 2024, and more dramatically in some markets, such as Sarasota. The national housing market may not be in a buyers’ market per se, but that is the vibe in Florida, as many sellers make price cuts or offer concessions, competing for a smaller buyer pool. In Texas, active listings are hitting record highs in some markets, such as Houston, while the median price is also seeing a slight decline, similar to Florida.

As of June 2025, both the Florida and Texas housing markets are facing headwinds, marked by rising inventory, increased price reductions, longer selling timelines, and shifting leverage toward buyers. This softening trend is pronounced throughout the Sun Belt, reflecting a transition away from the frenzied pandemic-era market.

The road ahead

Florida, Texas, and the broader Sun Belt markets are all contending with oversupply, softer pricing, and a shift toward buyer-friendly conditions. After years of strong gains, 2025 has brought a market reset, fueled by cooling migration, higher rates, and the lingering effects of pandemic-era overbuilding. In these regions, buyers now have more choice and negotiating power, while sellers face increasing competition and subdued price growth.

“Homes are sitting on the market nearly three weeks longer than last year,” Realtor.com’s Krimmel said. “That’s a sign of sellers still anchored to pandemic-era prices even though the market is telling them otherwise.”

Market watchers don’t expect a quick reversal. Prices are forecast to dip slightly by the end of 2025, but mortgage rates are predicted to hold nearly steady. For now, home-sale cancellations are likely to remain elevated, requiring all market participants to adapt to an era of higher uncertainty—and, for savvy buyers, greater opportunity.

For this story, Fortune used generative AI to help with an initial draft. An editor verified the accuracy of the information before publishing. 

South Korean Woman Convicted of Biting Man’s Tongue Receives Apology

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EPA Close-up of Choi Mal-ja, 78, raising her arms outside a court in Busan with a woman applauding behind her. She has dark curly hair and is wearing dark-framed glasses and a white top.EPA

Prosecutors in South Korea have apologised to a woman who was convicted for defending herself during a sexually violent attack more than 60 years ago.

Choi Mal-ja was sentenced to 10 months in prison, suspended for two years, for biting off part of her attacker’s tongue as he allegedly tried to rape her in 1964, when she was 18 years old.

Inspired by the country’s #MeToo movement, Ms Choi, now 78, has campaigned for years to have her conviction overturned.

Her retrial began in the city of Busan on Wednesday, where prosecutors issued an apology and asked for the court to quash her guilty verdict.

“For 61 years, the state made me live as a criminal,” Ms Choi told reporters outside the court ahead of the hearing.

She said she hoped future generations could live a happy life free from sexual violence.

At the start of the trial, Busan’s Chief Prosecutor Jeong Myeong-won said “we sincerely apologise”.

“We have caused Choi Mal-ja, a victim of a sex crime who should have been protected as one, indescribable pain and agony.”

A final ruling is scheduled for 10 September, with legal observers expecting the court to overturn Ms Choi’s conviction.

Outside the courtroom after the hearing, Ms Choi raised her fist and said: “We won!”

She celebrated by embracing campaigners from civic organisations who were there to support her.

In 1964, an 18-year-old Choi Mal-ja was attacked by a 21-year-old man, who forced his tongue into her mouth as he pinned her to the ground in the southern town of Gimhae, according to court records.

Ms Choi escaped the attack by biting off 1.5cm (0.59in) of the aggressor’s tongue.

The man was sentenced to six months in prison, suspended for two years, for trespassing and intimidation. He was never convicted of attempted rape.

Ms Choi was given a harsher sentence than her attacker for causing him grievous bodily harm.

The court at the time said her actions had exceeded the “reasonable bounds” of self-defence.

Ms Choi’s case has since been cited in legal textbooks in South Korea as a classic example of a court failing to recognise self-defence during sexual violence.

‘Justice is alive in this country’

After taking inspiration from South Korea’s #MeToo movement in the late 2010s, Ms Choi contacted advocacy groups to begin work on petitioning for a retrial.

She filed a petition in 2020, 56 years after the attack, but it was initially rejected by the lower courts. Three years later, the Supreme Court ruled that Ms Choi’s retrial could go ahead.

Her fight for justice became well known in South Korea, with Ms Choi and fellow activists holding protests outside the Supreme Court building in Seoul.

“I still can’t believe it,” Ms Choi said after Wednesday’s hearing, the Korea JoongAng Daily newspaper reported.

“But if the prosecution is admitting its mistake even now, then I believe justice is alive in this country.”

AEG Presents UK and European Festivals appoints Jim King as CEO

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Live events company AEG Presents has promoted Jim King to CEO of AEG Presents UK and European Festivals.

King, who was most recently CEO of European Festivals, will now also oversee the company’s UK concert promotion business, which includes arena and stadium tours as well as club performances.

In addition, Steve Homer will transition to a new position as President of UK Touring at the company as part of King’s team.

According to AEG Presents, in his new role, Homer will focus on AEG Presents’ UK touring business, “leveraging his long-standing relationships and experience as one of the country’s leading concert promoters”.

AEG Presents noted that “from [his] formative start at Cream, where he produced the pioneering Creamfields festival, to launching celebrated events like RockNess and Bestival, King has long been at the forefront of live music innovation”.

King joined AEG Presents in 2008 and has led the creation and production of flagship festivals including BST Hyde Park, featuring global superstars such as Adele, Elton John, Olivia Rodrigo, The Rolling Stones, Stevie Nicks, and Bruce Springsteen, as well as All Points East, hosting acts like LCD Soundsystem, Mitski, Stormzy, and Chase & Status.

He also oversees Rock en Seine in Paris and co-launched Bristol’s Forwards Festival with Team Love in 2022. His latest project is the launch of LIDO in London’s Victoria Park.

“Jim’s appointment is both a recognition of his achievements and a key strategic step as we continue aligning and expanding our UK and European business strategies,” said Adam Wilkes, President & CEO of AEG Presents Europe and Asia Pacific, to whom King will report.

“Jim’s appointment is both a recognition of his achievements and a key strategic step as we continue aligning and expanding our UK and European business strategies.”

Adam Wilkes, AEG Presents Europe and Asia Pacific

Added Wilkes: “His vision and leadership have been central to shaping the company’s presence and footprint across the region, and I’m confident that under his guidance we’re well positioned for even greater success in the United Kingdom and across the continent.

“In addition, I’m thrilled that Steve will pivot to his new role, where he can focus on what he does best — bringing his talents as a gifted concert promoter to our newly realigned business.”

“AEG Presents has been my home for nearly 20 years now, and I’ve never been more excited about the opportunities ahead.”

Jim King

King added: “It’s a privilege to take on this role at a time when the live entertainment landscape is evolving rapidly. AEG Presents has been my home for nearly 20 years now, and I’ve never been more excited about the opportunities ahead.”

“I’m grateful to Adam and Jay Marciano [Chairman and CEO, AEG Presents] for their trust in me as we continue to build our business throughout the region with our extraordinary team, and I’m looking forward to working even more closely with Steve as we shape the future of our UK live event strategy.”

The promotions mark the latest executive moves across AEG Presents’ global network. Two weeks ago, Dion Brant, the CEO of AEG Presents’ Australian concert promoter Frontier Touring, was appointed President and CEO of AEG Presents Asia Pacific.

In May, Joe Jaeger was promoted to Vice President, Integrated Marketing and Strategy, within AEG’s Global Partnerships division. In March, AEG promoted seven executives to SVP roles including Andrew Bersch to SVP of Finance & Administration, Holli Branam, Bret Heiman and Alex McArthur to SVP of Sales, Samantha Fernandez to SVP of Festival Activations, and Brianne Grimley to SVP of Venue Activations. Eric Kohler has also been promoted to SVP of Global Partnerships.

In February, Andrew Klein was promoted to President of Global Partnerships. AEG has also announced several other notable appointments in recent months, including Angie Rho’s appointment to Senior Vice President, Global Touring, and Weston Herbert’s appointment to Vice President, Global Touring in January.

Music Business Worldwide

Ukrainian Protests Erupt as President Zelenskyy Enacts Legislation Limiting Anticorruption Agencies | Updates on Civil Rights

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President Volodymyr Zelenskyy has signed a controversial bill that hands sweeping authority to Ukraine’s prosecutor general over the country’s independent anticorruption agencies.

This triggered the largest antigovernment protests on Tuesday since Russia’s full-scale invasion began in 2022. More protests are expected Wednesday.

The new legislation, now law, gives the prosecutor general power to control and reassign investigations led by the National Anticorruption Bureau (NABU) and the Specialised Anti-Corruption Prosecutor’s Office (SAPO).

NABU and SAPO are two key institutions that have long symbolised Ukraine’s post-Euromaidan commitment to rooting out high-level corruption. Critics say the move strips these agencies of their independence and risks turning them into political tools.

Protests erupted in Kyiv, Lviv, Dnipro, and Odesa, with demonstrators holding signs reading “Veto the law” and “We chose Europe, not autocracy.”

Many saw the legislation as a betrayal of Ukraine’s decade-long push towards democratic governance, transparency, and European Union membership.

Just one day prior, Ukraine’s domestic security agency arrested two NABU officials on suspicion of Russian links and searched other employees.

Zelenskyy, in his Wednesday address, cited these incidents to justify the reform, arguing the agencies had been infiltrated and that cases involving billions of dollars had been stagnant.

“There is no rational explanation for why criminal proceedings worth billions have been hanging for years,” he said.

But watchdogs and international observers see a different danger.

Transparency International Ukraine warned that the law dismantles critical safeguards, while the EU’s enlargement commissioner, Marta Kos, called it “a serious step back”.

The EU, G7 ambassadors, and other Western backers emphasised that NABU and SAPO’s independence is a prerequisite for financial aid and EU accession.

Despite Deputy Prime Minister Taras Kachka’s assurances that “all core functions remain intact,” disillusionment is growing.

Dmytro Kuleba, Ukraine’s former foreign minister, declared it “a bad day for Ukraine”, underscoring the stark choice Zelenskyy faces: Stand with the people – or risk losing their trust, along with Western support.

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Comparing the Top 15 Rolling Duffel Bags of 2025: A Detailed Review

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Simplicity and ruggedness make duffel bags a great choice for travel, and things get even more exciting when you add wheels.

A rolling duffel bag is in a league of its own. It’s not quite a suitcase and it’s not quite a duffel bag—it’s somewhere in between, which means you get the best of both worlds. When you need to carry a hefty amount of gear, a rolling duffel bag might just be your best bet.

It’s a bit of a niche product. Most luggage brands don’t make rolling duffels, and most backpack brands don’t, either. There are a few companies out there who are leading the charge, like Eagle Creek, Osprey and Db.

If you just want our top pick for the single best rolling duffel bag on the market, check out the Eagle Creek Cargo Hauler XT. It’s tough and functional, and it comes in a range of sizes. We also were impressed by the Db Hugger, which features an innovative “rib cage” design that adds structure and protection for your gear.

Of course, there’s no one-size-fits-all answer. I’ll guide you through our top 15 duffel bag picks and help you decide which fits your needs.

Why Trust TravelFreak?

Every member of the TravelFreak team is an avid traveler and adventurer. We all love the massive carrying capacity and easy packability of duffel bags, and we’ve stuffed various duffels with clothes for a month abroad, equipment for long-distance treks, and climbing gear for days at the crag.

We’ve tested dozens of duffel bags, and most of the bags in our collection have seen more than their share of abuse. We dragged them over miles of cobblestone and tossed them off bus roofs.

We are serious about finding and recommending the absolute best gear on the market. Because of that, we weren’t satisfied with the surface-level, seat-of-the-pants style of reviewing you see so often on the internet.

So we got our team of gear junkies and former product engineers together to develop the most in-depth and comprehensive test methodology for rating luggage and bags. We now evaluate every product over 29 specific metrics across eight categories to get an objective picture of how the bag performs.

We dug into the nitty gritty details of these duffel bags so you don’t have to. Every bag on this list earned our full vote of confidence for its intended use case.

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Eagle Creek Cargo Hauler XT 29

Eagle Creek is one of my favorite brands for rugged, adventure-ready travel gear. Unlike travel brands that sacrifice build quality and functionality for style, Eagle Creek puts durability and usability first. Their products are utilitarian and ready for whatever you throw at them.

The Eagle Creek Cargo Hauler XT easily earned our top pick for the best rolling duffle bag overall. It’s rugged, simple, and well-designed.

The build quality alone makes this rolling duffle bag stand out from the crowd. It’s made with a combination of 800D nylon and 1680D ballistic polyester fabric.

The smooth-rolling wheels are huge and have grippy rubberized tires that make them quiet and very durable. Compared to most luggage wheels, these burly oversized wheels seem ready for all sorts of off-road adventures.

It also is backed by Eagle Creek’s awesome No Matter What Warranty. If it ever breaks, Eagle Creek will fix it. It’s as simple as that.

Most rolling duffle bags are just that. The only logical way to move them is by wheeling them around. They have grab handles, but those are more for hefting them in and out of vehicles. The Cargo Hauler XT adds something I rarely see in wheeled duffel bags: backpack shoulder straps.

While the backpack mode isn’t as comfortable as a full-on hiking backpack, it offers an alternative way to carry the bag. This is great if you’re moving up and down stairs or over rougher terrain where wheels won’t cut it.

Of course, even our top pick isn’t perfect. If you like multiple compartments for organization, this bag is okay, but not the best. The interior is mainly one huge cavernous space, and it’s easy for stuff to get lost down in the bottom. I highly recommend using packing cubes to stay organized.

If you’re on the hunt for a wheeled duffel bag that combines rugged durability with smart features, the Eagle Creek Cargo Hauler is worth a look.

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AmazonBasics Ripstop Wheeled DuffelAmazonBasics Ripstop Wheeled Duffel

I’m like most people out there—when I’m on a tight budget, Amazon is the first place I shop. While you can find a lot of cheap, poorly-made products on Amazon, there are also a handful of cheap, decent products that are still well-made. Surprisingly, Amazon’s in-house brand, AmazonBasics, is a pretty solid choice.

The AmazonBasics Ripstop Wheeled Duffel is less than half the price of most duffel bags on this list, and it will work great for 90% of people.

Surprisingly, for a budget pick, this bag is loaded with features. There are multiple exterior pockets to keep things handy. External and internal compression straps help keep everything secure. There are even separate compartments for shoes and dirty laundry.

Most importantly, this bag just works. The roller wheels are smooth and surprisingly sturdy. The spacious main compartment has tons of room for everything you want to throw in there.

While it may not be the best pick for frequent travelers, I think this AmazonBasics rolling duffle bag is perfect for more occasional travel or long-haul road trips.

Of course, the build quality is not going to be on par with brands like Eagle Creek and Osprey. If you want a rolling duffle bag that will last the rest of your life, it’s worth investing in something higher quality. But if you just need a cheap, capable, durable enough bag, this AmazonBasics duffel is more than adequate.

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Db Hugger 90L: Best Rolling Duffel Bag for Checked Luggage

Db Hugger 90L RollerbagDb Hugger 90L Rollerbag

The Db Hugger 90L is unlike any other duffel bag we tested. The unique design and construction make it a fantastic choice for check-in wheeled luggage.

It all starts with Db’s innovative rib cage technology. Most duffel bags are unstructured and flexible, and they don’t offer much protection for the contents. Hard shell suitcases offer much better protection, but they come with their own host of issues. Using a unique rib cage design, Db created a rolling duffle bag that is stronger and more protective.

Essentially, the Hugger is a normal fabric bag with semi-rigid molded ABS “ribs” sewn in and plenty of foam padding in the spaces between the ribs. This design has several advantages over a standard fabric duffle bag.

First, it provides much better protection. With the skeleton-like construction and the ample padding, I don’t worry about my gear getting smashed or dented during travel—that’s especially welcome when I’m traveling with expensive sports gear. And yes, those airport baggage handlers seem to have a mission to break anything fragile in my suitcase.

Second, the additional structure means this bag doesn’t collapse into itself when empty. That makes it much easier to pack and unpack.

Third, the bag holds its shape even when it isn’t fully packed. No more ugly saggy bag drooping along behind you.

The Db Hugger is very minimal in design. There’s a wraparound zipper that opens the entire front panel to expose a huge main compartment. There are a few mesh pockets along the inside for small items. And that’s it. No compression straps. No complicated organization systems. It’s just a big, empty volume to pack your stuff.

Honestly, that’s pretty refreshing when so many rolling duffels these days are loaded with unnecessary features. However, it would be nice to have one zippered pocket on the outside to keep small items handy.

This bag is awesome, but it isn’t for everyone. It’s one of the most expensive rolling duffel bags we tested, and many people will do just fine with less expensive wheeled duffels. It’s designed for serious travelers who want the best durability and protection available.

What We Considered

There’s a lot that goes into choosing a good rolling duffel bag. What material does it use? Is it carry-on compliant? Can the wheels handle the abuse of frequent travel?

We break our testing and rating for rolling duffel bags and luggage into eight categories: build quality, ease of use, functionality, water resistance, brand impact, buying experience, warranty, and price-to-performance ratio.

Within each category there are several specific factors we look at to choose the best bags.

These considerations can also help you know what to look for while shopping for a new bag.

Build Quality

A rolling duffel bag is an investment that should last for many years of travel. That’s why build quality is our top consideration for choosing the best rolling duffel bags. A bag may be stylish and feature-packed, but if it falls apart after a few trips, it isn’t worth spending your hard-earned money on it.

We’ve spent enough time traveling and testing duffel bags to know where they fail and what makes the difference for the ones that can handle abuse.

  • Zippers are almost always the first thing to break in a duffel bag. We like big, chunky zippers that can take some abuse, and we’ve found YKK-brand zippers to be the best.
  • The bag’s main material plays an important role in durability. Heavy-duty Cordura nylon or laminated fabrics like X-Pac are some of our favorites for backpacks.
  • Components like buckles and adjusters are also easy to break. We look for big, heavy-duty buckles.
  • A durable duffel bag should have reinforcements in high-wear areas like the bottom.
  • Stitch quality can make the difference between two bags that use the same materials. We look for backpacks with tight, even stitches and cleanly finished seams that won’t come apart.

Ease of Use

A rolling duffel bag should be simple, streamlined, and easy to use. Here are some key features we look at when rating a bag for ease of use.

  • Packing and organization should be straightforward in a duffel bag. We like pockets and features, but too many can be overwhelming.
  • The telescoping handle should be sturdy, intuitive, and adjustable. The more adjustment positions the better.
  • Good maneuverability makes a bag easier to handle in airports or through city streets. We want bags with smooth-rolling wheels
  • Grab handles are essential for lifting and carrying a duffel bag. In our experience, it’s hard to have too many.

Functionality

Ultimately, any duffel bag’s job is to carry stuff. That isn’t complicated, but some bags do a better job than others. Plus, different bags may have different intended uses, which changes their features and function.

For example, a duffel bag for urban carry-on travel should have more compartments for keeping devices and accessories organized, while a duffel for adventure travel needs to be simple and ultra-durable for hauling outdoor gear.

We evaluate how well a duffel bag fulfills its intended purpose. Does it carry everything we need it to? Does it keep the contents safe and protected?

Water Resistance

We’ve all been caught out in the rain on our travels, and having a water-resistant bag gives us confidence that we won’t end up with a pile of soaked clothes.

Here are the three aspects we look at to judge a bag’s water resistance.

  • Water-resistant fabric ranges from thin DWR coatings that wear out quickly to laminated fabrics with completely waterproof layers.
  • Water-resistant zippers stop water from penetrating through zippered openings.
  • Duffel bags with taped or sealed seams are the most waterproof on the market.

Brand Impact

It is important to us to support and recommend brands that have a positive impact on the world. We want to support brands that are working to incorporate environmentally friendly policies, sustainable design, diversity and inclusion, and good factory working conditions. To avoid greenwashing, we look for rigorous and widely respected industry certifications.

Here are some specific factors we look at to find brands that are working toward a positive impact on the world:

  • Sustainable Materials
  • Emission Reduction Programs
  • Carbon Neutral Certification
  • B-Corp Certification
  • Regular Impact Reporting
  • Fair Trade Certified Manufacturing

Buying Experience

Shopping for and buying a new duffel bag should be a rewarding experience. We value companies that implement specific policies to reduce the stress and risk of buying a product.

A good buying experience includes free shipping and hassle-free return policies. You can be a lot more confident in buying the right bag if you can test it first.

Warranty

It gives us a lot of confidence when brands stand behind their products. We look for companies that offer reliable lifetime warranties that cover incidental damage.

Price-to-Performance

We believe in investing in high-quality gear that will last. It’s better to buy a higher-quality (but possibly more expensive) product the first time rather than buy a cheaper one and end up replacing it later. That said, you don’t have to empty your bank account to get a good rolling duffel bag.

The sweet spot is a well-built bag that fits your needs without a luxury price tag.

Impact of Sugar on Gut Bacteria and Immune Response

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A groundbreaking study has revealed that white sugar doesn’t just feed the bacteria in your gut – it rewires them. Researchers have discovered that consuming sugar can trigger physical flips in bacterial DNA, setting off a chain reaction that alters immune responses and gut health. It’s a finding that adds new weight to concerns about sugar’s hidden impacts – and opens the door to a new understanding of how diet directly shapes disease risk at the molecular level.

Scientists at the Technion-Israel Institute of Technology investigated how dietary components – in this case, white sugar – could change the genetic behavior of gut bacteria, and what the potential health impacts of this could be. Their focus was on one species in particular – Bacteroides thetaiotaomicron, a dominant species in the microbiome that helps regulate inflammation, preserve the gut lining, digest complex carbohydrates and protect against pathogens.

Looking first at cell culture and then mice, and finally humans, the researchers found that dietary refined sugar had a strange impact on B. thetaiotaomicron, causing it to undergo DNA inversion – a type of phase variation that sees sections of its genetic code flip direction. And it wasn’t a mutation but a temporary “costume change” that allowed the bacteria to alter what genes it switched on and off. These genes mostly coded for surface-layer proteins, essentially enabling the bacteria to change up its appearance – but this also altered its normally beneficial gut roles.

Phase variation like this is normally seen in pathogens like Salmonella and E. coli to dodge interception by immune cells or antibiotics. For this good bacteria, it’s induced by refined white sugar.

This sugar-triggered microbial disguise also changed how the immune system “saw” the friendly locals and responded. While not demonstrated in the human stool samples that unlocked this DNA inversion mystery, a different outer appearance of B. thetaiotaomicron could trigger the immune system to perceive the bacteria as a threatening foreigner and mount an attack, heightening the risk of inflammation and gut lining damage.

In the study, the researchers found that consuming sugary carbonated drinks that contain white sugar can trigger this DNA inversion. They also observed shifts in inflammatory markers, such as cytokines, suggesting a systemic immune response to the shapeshifting bacteria. It’s the first time scientists have observed this microbial gene-switching mechanism triggered by sugar in the human gut.

The good news is that this DNA inversion is temporary, with the bacteria switching back to their normal appearance once the sugar rush is over, however, repeated exposure amplifies this effect and could lead to more serious gut issues and chronic inflammation.

While the study doesn’t prove that sugar is a serious threat to overall gut health, it does reveal how enough of it will coax beneficial bacteria like B. thetaiotaomicron to act like a pathogen, which warrants further study on the long-term impact of this DNA inversion. It could also help develop specific probiotics that suppress the genetic switching, and help guide dietary recommendations for those prone to the kind of gut problems the disguised microbe could trigger or worsen.

“By studying the effects of specific dietary components on the immune-modulatory functionality of key members of the gut microbiota, tailored dietary recommendations can be given to human subjects based on their microbiome composition,” added the researchers.

The study was published in the journal Nature Communications.

Source: Technion-Israel Institute of Technology

Son of British couple detained in Afghanistan issues warning that they may face death in prison

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The son of a British couple detained by the Taliban five months ago has told the BBC that he fears they may die in prison.

Peter Reynolds, 80, and Barbie, 76, were arrested on 1 February while returning to their home in central Bamiyan province, Afghanistan.

Their son Jonathan Reynolds said their health was rapidly deteriorating, with his father suffering serious convulsions and his mother “numb” from anaemia and malnutrition.

It is not known exactly why they were detained, and a Taliban official told the BBC in February that the group planned to release the couple “as soon as possible”.

The UN has also warned that they could perish “in such degrading conditions” if they do not receive medical care at once, calling their detention “inhumane”.

Mr Reynolds said it had been a “harrowing and surreal” five months waiting for the release of his parents, who lived in Afghanistan for 18 years, where they had citizenship and ran education projects.

One of these projects involved training women and children and had apparently been approved by local authorities, despite the Taliban banning education for girls over 12-years-old and not allowing women to work.

Mr Reynolds said his parents had been held in harsh conditions – including a maximum security prison – despite being “deemed innocent” by a judge and facing no charges.

“My dad was chained to murderers and criminals,” he told BBC Radio 4’s Today programme, adding that they had at one point been held in a basement for six weeks without sunlight, and not allowed out.

The couple revealed “just how bad their health is” when they last had contact with their children on 15 June, Mr Reynolds said.

“My dad’s health is deteriorating fast in particular,” he said of the 80-year-old, who has a history of minor heart attacks.

“Now he’s maybe got something like early Parkinson’s – tremors and shakes down the right side of his body, his arms and face,” he told BBC Breakfast.

He added that his father spent “half an hour convulsing on the prison floor” before his wife called for a prison guard to move him onto a “mattress pad on the floor” serving as a bed.

Mrs Reynolds “has blue hands and feet to do with anaemia, malnutrition, just not getting the right healthcare,” he added.

Mr Reynolds said he did not know his parents’ exact location – and that he was unsure “that the demand has been made for their immediate release”.

“Every week it seems like we’re told ‘just wait two or three more days now… just hang tight’.

“Week after week we’re told that – and they’re still in prison.”

However, he said he was grateful to the Foreign Office (FCDO) for the level of communication with the family.

The couple have both had birthdays in prison, and last week marked their 55th wedding anniversary; they married in Kabul in 1970.

Mr Reynolds said: “I’m thankful they were together, but they’re certainly not free.”

The UN likewise warned on Monday that the pair’s health was quickly declining, and questioned why they were being held at all.

“Without access to adequate medical care, they are at risk of irreparable harm or even death,” read a statement by the UN’s human rights body, which called for their immediate transfer to a civilian hospital.

“We see no reason why this older couple should be detained at all, and have requested an immediate review of the grounds of their detention.

“It is inhumane to keep them locked up in such degrading conditions and more worrying when their health is so fragile.”

It added that it had raised the couple’s case with the Taliban and the UK.

Taliban official Abdul Mateen Qani said in February: “A series of considerations is being taken into account, and after evaluation, we will endeavour to release them as soon as possible.”

The FCDO has been approached for a response.

The UK shut its embassy in Kabul and withdrew its diplomats from the country after the Taliban returned to power in 2021.

The FCDO says support for British nationals in Afghanistan is therefore “severely limited” and advises against all travel to the country.

Stora Enso’s Q2 operational EBIT exceeds expectations, leading to rise in shares

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Stora Enso shares rise as Q2 operational EBIT beats estimates

Driver charged with attempted murder in US after ramming car into LA nightclub

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If convicted, Fernando Ramirez could face multiple sentences of life imprisonment.

A man accused of deliberately driving his car into a crowd of pedestrians in the United States, outside a Los Angeles nightclub in California over the weekend, has been charged with 37 counts of attempted murder, according to prosecutors.

Fernando Ramirez, 29, a resident of Orange County’s San Clemente, was also charged on Tuesday with 37 counts of assault with a deadly weapon, according to a statement from the Los Angeles County District Attorney’s Office. If convicted, he could face multiple sentences of life imprisonment.

The suspect is accused of intentionally driving his car onto the pavement as partygoers were leaving the Vermont Hollywood venue at the end of a reggae hip-hop event early on Saturday. The motive for the attack, which injured 37 people, remains unknown.

Ramirez, who is currently being held without bail, will be arraigned on Wednesday. The public defender’s office said they have not been appointed to represent him.

“When he drove that car onto that sidewalk, he aimed it at a whole sea of pedestrians,” LA County District Attorney Nathan Hochman said in announcing the charges.

The car came to a stop after colliding with several food carts, which became lodged underneath the vehicle, and bystanders attacked the driver, police said. A total of 37 people were hurt, with injuries ranging from minor abrasions to serious fractures and lacerations, prosecutors said. The criminal complaint alleges that Ramirez inflicted great bodily injury on eight of the victims.

Police said officers dispatched to the scene found that Ramirez had been shot while being assaulted by onlookers and was himself taken to a hospital, his condition unknown. A man suspected of shooting the motorist fled the scene on foot, according to police, who were still looking for the attacker on Tuesday.

“We understand that this brazen act has shaken the community and but for the good grace of God, this could have been a mass casualty incident,” Hochman said.

Among those injured, 23 people were taken to hospitals, said Ronnie Villanueva, interim fire chief of the Los Angeles Fire Department.

Los Angeles police chief Jim McDonnell said, “It’s truly a miracle that no one was killed that day.”

Ramirez has a criminal history that includes a battery and gang-related charge in 2014, an aggravated battery conviction for a 2019 attack on a Black man at a Whole Foods grocery store in Laguna Beach, California, and a domestic violence charge in 2021, records show.

Ramirez “has proved to be violent to strangers and family alike and clearly has a lack of concern for the safety of others”, Orange County prosecutors said in a court filing for the 2019 attack.

A 2024 drink-driving case and 2022 domestic violence charge were pending at the time of the nightclub crash, according to records.