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mRNA COVID Vaccine Associated with Doubling Survival Rate During Cancer Therapy

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Getting a COVID shot might do more than protect against the virus – it could also help cancer patients live longer. A new study found that mRNA vaccines were linked to a doubling in three-year survival for those on immunotherapy.

Cancer immunotherapy helps the body’s own immune system recognize and attack cancer cells. Normally, cancer can hide in the body using “checkpoint” proteins that tell the immune system not to attack. Immune checkpoint inhibitors (ICIs) block these proteins, removing the invisibility cloak from cancer cells and helping the immune system fight them more effectively.

Now, a new study led by the University of Texas MD Anderson Cancer Center and the McKnight Brain Institute at the University of Florida has found that an unlikely source provides a significant boost to the effectiveness of cancer immunotherapy: mRNA-based COVID vaccines.

“This study demonstrates that commercially available mRNA COVID vaccines can train patients’ immune systems to eliminate cancer,” said co-lead author Adam Grippin, MD, PhD, a radiation oncology resident at the MD Anderson Cancer Center. “When combined with immune checkpoint inhibitors, these vaccines produce powerful antitumor immune responses that are associated with massive improvements in survival for patients with cancer.”

Killer T-cells surround a cancer cell (center) to deliver the “kiss of death”

Wikimedia Commons/National Institutes of Health

mRNA vaccines like those developed by Pfizer and Moderna for SARS-CoV-2 work by giving your body a tiny genetic instruction – messenger RNA – that tells cells to make a harmless piece of the coronavirus spike protein. The immune system sees this protein as foreign and builds antibodies and memory cells to fight it. Later, if you’re exposed to the real virus, your body recognizes the spike protein quickly and mounts a fast, strong defense to prevent infection or severe illness.

In the present study, the researchers examined how mRNA COVID-19 vaccines affect cancer patients who are receiving ICIs. They wanted to know if vaccination might trigger immune-related side effects, worsen cancer outcomes, or interfere with the safety and effectiveness of the ongoing immunotherapy.

The researchers collected data from a large, multicenter cohort of patients actively receiving ICIs for solid tumors. They compared vaccinated and unvaccinated patients, looking particularly at adverse events after vaccination (especially immune-related ones such as myocarditis, colitis, or pneumonitis), cancer progression or recurrence rates, and overall survival and hospitalization rates.

The study used both retrospective data analysis and prospective monitoring of patients for several weeks after each vaccine dose. Some lab-based immune profiling was also done to measure antibody and T-cell responses. T-cells are crucial for immune protection because they eliminate infected or cancerous cells and coordinate the overall immune response.

mRNA vaccines were found to be generally safe in patients receiving immunotherapy. The rate of immune-related adverse events did not increase after vaccination compared to baseline ICI rates. Common short-term vaccine side effects like fever, fatigue, or arm pain were mild and temporary, similar to those seen in the general population.

Most patients developed strong antibody responses after two vaccine doses. Those with blood (hematologic) cancers or undergoing intense chemotherapy alongside ICI had slightly weaker responses, but still meaningful immune system protection. Booster doses further improved antibody and T-cell levels. Importantly, there was no evidence that vaccination accelerated disease progression or worsened cancer control. Vaccinated patients tended to have lower rates of severe COVID-19 infection, hospitalization, and death.

One of the most striking results from the study was the link between COVID-19 vaccination and long-term survival among cancer patients receiving immunotherapy. According to the study data, patients who received at least one dose of an mRNA COVID vaccine within 100 days of starting ICI were about twice as likely to be alive three years later compared to those who remained unvaccinated.

The researchers suggested several possible reasons for this survival benefit. Vaccinated patients were much less likely to develop severe COVID-19, which can be especially dangerous for people with weakened immune systems. Avoiding infection also meant fewer interruptions to cancer treatment, allowing patients to continue their immunotherapy as planned. There’s also speculation that the immune stimulation caused by the vaccine might enhance the body’s antitumor immune response, though that hypothesis needs further study.

Cancer patients had double the survival rate if they received at least one COVID vaccine during treatment
Cancer patients had double the survival rate if they received at least one COVID vaccine during treatment

Importantly, the researchers’ analysis took into account age, cancer type, disease stage, and treatment duration, suggesting that the survival advantage was not simply due to healthier patients being more likely to get vaccinated. However, because the study was observational, the authors caution that they can’t prove causation – only that vaccination was strongly associated with improved outcomes.

“The really exciting part of our work is that it points to the possibility that widely available, low-cost vaccines have the potential to dramatically improve the effectiveness of certain immune therapies,” Grippin said. “We are hopeful that mRNA vaccines could not only improve outcomes for patients being treated with immunotherapies but also bring the benefits of these therapies to patients with treatment-resistant disease.”

A multicenter, randomized Phase 3 trial is currently being designed to validate these findings and investigate whether mRNA COVID vaccines should become part of the standard care for patients receiving ICIs.

The study was supported by the National Cancer Institute, the National Institutes of Health, the Food and Drug Administration, the American Brain Tumor Association, the Radiological Society of North America, Conquer Cancer Foundation of ASCO, CureSearch for Children’s Cancer, Stop Children’s Cancer/Bonnie R Freeman Professorship for Pediatric Oncology Research, Danny’s Dream, Ian’s Friends Foundation Inc., Alex’s Lemonade Stand Foundation, The Medulloblastoma Initiative and Cure Group 4 Consortium, and the National Pediatric Cancer Foundation.

For a full list of the authors’ conflict-of-interest disclosures, including funding sources, please refer to the study, which was published in the journal Nature.

Source: University of Texas MD Anderson Cancer Center

Kakao founder cleared of accusations of stock manipulation during competition with HYBE

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The billionaire founder of South Korea’s Kakao Corp. has been found not guilty in a criminal trial involving Kakao’s bidding war against HYBE for K-pop agency SM Entertainment.

The Seoul Southern District Court on Tuesday (October 21) acquitted Kim Beom-su of charges of violating the Capital Markets Act, concluding prosecutors hadn’t proven their case that Kakao’s purchases of SM Entertainment stock amounted to stock price manipulation.

“Based on evidence from the prosecution, it is difficult to recognize that there were discussions to collude in stock manipulation,” the court said, as quoted by The Korea Herald.

“Kakao’s stock purchase orders differ significantly from those typically associated with price manipulation, considering the time intervals and methods of purchase. It is also difficult to see whether there was any intent to artificially fix prices at levels higher than normal market values.”

The court also handed down acquittals to Kakao itself and Kim’s co-defendants, which included former Kakao chief investment officer Bae Jae-hyun, Kim Sung-soo, CEO of subsidiary Kakao Entertainment, former Kakao CEO Hong Eun-taek, former Kakao investment strategy head Kang Ho-jung and One Asia Partners President Kim Tae-young.

One Asia Partners is a private equity fund management firm with links to Kakao that prosecutors alleged was involved in the scheme.

Prosecutors had sought a 15-year prison sentence for Kim, along with a fine of 500 million Korean won (USD $350,000). They alleged that Kim was the leader of a plot inside Kakao to drive up SM Entertainment’s stock price in February 2023, when entertainment giant HYBE was attempting to acquire SM Entertainment.

Prosecutors said the scheme involved funneling some KRW 240 billion ($172 million) across more than 300 individual transactions, causing SM Entertainment stock to rise dramatically.

Around that time, SM’s shares briefly spiked from around KRW 75,000 per share to more than KRW 147,000, before falling back down again. HYBE’s offer to buy SM, a rival K-pop company, fell through and Kakao Corp. tabled its own bid. Kakao eventually emerged as the winner in the bidding war, taking a 39.9% stake in SM Entertainment.

Then began a two-and-a-half-year-long legal ordeal for Kakao, which is one of South Korea’s most prominent tech and entertainment companies. It owns the popular messaging app KakaoTalk and music streaming service Melon.

“Based on evidence from the prosecution, it is difficult to recognize that there were discussions to collude in stock manipulation.”

Seoul Southern District Court

It’s also a major shareholder of KakaoBank, something that could have posed a major headache for Kakao if Kim had been convicted. Under South Korean law, an entity convicted of financial crimes can’t own more than 10% of a bank. Kakao, which owns around 27% of KakaoBank, would have been forced to divest its holdings, jeopardizing its control over the financial institution.

Kim was arrested in July 2024 and indicted the following month. He spent 100 days in custody before being released on bail with restrictions on his movements, according to Korea JoongAng Daily.

“For two years and eight months, Kakao group endured many difficulties due to the investigation and trial,” the company said in a statement quoted by The Herald.

“The difficulty in responding quickly to rapid market changes is particularly painful. We will strive to overcome this and fulfill our social responsibility.”

According to JoongAng Daily, the acquittals remove a major obstacle for Kakao, which had been falling behind in developing new products amid the investigation and trial.

The company is currently focused on integrating AI chatbots into its KakaoTalk app, and has been exploring the potential of creating a stablecoin linked to the value of the South Korean won.Music Business Worldwide

Gender Equity: Mahnoor Omer, 25, Sues Pakistan Over Menstrual Rights

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Growing up in Rawalpindi, a city adjacent to Pakistan’s capital Islamabad, Mahnoor Omer remembers the shame and anxiety she felt in school when she had periods. Going to the toilet with a sanitary pad was an act of stealth, like trying to cover up a crime.

“I used to hide my pad up my sleeve like I was taking narcotics to the bathroom,” says Omer, who comes from a middle-class family – her father a businessman and her mother a homemaker. “If someone talked about it, teachers would put you down.” A classmate once told her that her mother considered pads “a waste of money”.

“That’s when it hit me,” says Omer. “If middle-class families think this way, imagine how out of reach these products are for others.”

Now 25, Omer has gone from cautious schoolgirl to national centrestage in a battle that could reshape menstrual hygiene in Pakistan, a country where critics say economics is compounding social stigma to punish women – simply for being women.

In September, Omer, a lawyer, petitioned the Lahore High Court, challenging what she and many others say is effectively a “period tax” imposed by Pakistan on its more than 100 million women.

Pakistani governments have, under the Sales Tax Act of 1990, long charged an 18 percent sales tax on locally manufactured sanitary pads and a customs tax of 25 percent on imported ones, as well as on raw materials needed to make them. Add on other local taxes, and UNICEF Pakistan says that these pads are often effectively taxed at about 40 percent.

Omer’s petition argues that these taxes – which specifically affect women – are discriminatory, and violate a series of constitutional provisions that guarantee equality and dignity, elimination of exploitation and the promotion of social justice.

In a country where menstruation is already a taboo subject in most families, Omer and other lawyers and activists supporting the petition say that the taxes make it even harder for most Pakistani women to access sanitary products. A standard pack of commercially branded sanitary pads in Pakistan currently costs about 450 rupees ($1.60) for 10 pieces. In a country with a per capita income of $120 a month, that’s the cost of a meal of rotis and dal for a low-income family of four. Cut the cost by 40 percent – the taxes – and the calculations become less loaded against sanitary pads.

At the moment, only 12 percent of Pakistani women use commercially produced sanitary pads, according to a 2024 study by UNICEF and the WaterAid nonprofit. The rest improvise using cloth or other materials, and often do not even have access to clean water to wash themselves.

“If this petition goes forward, it’s going to make pads affordable,” says Hira Amjad, the founder and executive director of Dastak Foundation, a Pakistani nonprofit whose work is focused on promoting gender equality and combating violence against women.

And that, say lawyers and activists, could serve as a spark for broader social change.

The court docket describes the case as Mahnoor Omer against senior officials of the government of Pakistan. But that’s not what it feels like to Omer.

“It feels like women versus Pakistan.”

Activists of Mahwari Justice, a menstrual rights group, distributing period kits to women in Pakistan [Photo courtesy Mahwari Justice]

‘It’s not shameful’

Bushra Mahnoor, founder of Mahwari Justice, a Pakistani student-led organisation whose name translates to “menstrual justice”, realised early just how much of a struggle it could be to access sanitary pads.

Mahnoor – no relation to Omer – grew up in Attock, a city in the northwestern part of Pakistan’s Punjab province, with four sisters. “Every month, I had to check if there were enough pads. If my period came when one of my sisters had hers too,” finding a pad was a challenge, she says.

The struggle continued in school, where, as was the case with Omer, periods were associated with shame. A teacher once made one of her classmates stand for two entire lectures because her white uniform was stained. “That was dehumanising,” she says.

Mahnoor was 10 when she had her first period. “I didn’t know how to use a pad. I stuck it upside down; the sticky side touched my skin. It was painful. No one tells you how to manage it.”

She says that shame was never hers alone, but it’s part of a silence which starts at home and accompanies girls into adulthood. A study on menstrual health in Pakistan shows that eight out of 10 girls feel embarrassed or uncomfortable when talking about periods, and two out of three girls report never having received information about menstruation before it began. The findings, published in the Frontiers in Public Health journal in 2023, link this silence to poor hygiene, social exclusion and missed school days.

In 2022, when floods devastated Pakistan, Mahnoor began Mahwari Justice to ensure that relief camps did not overlook the menstrual needs of women. “We began distributing pads and later realised there’s so much more to be done,” she says. Her organisation has distributed more than 100,000 period kits – each containing pads, soap, underwear, detergent and painkillers – and created rap songs and comics to normalise conversations about menstruation. “When you say the word ‘mahwari’ out loud, you’re teaching people it’s not shameful,” she says. “It’s just life.”

The same floods also influenced Amjad, the Dastak Foundation founder, though her nonprofit has been around for a decade now. Its work now also includes distributing period kits during natural disasters.

But the social stigma associated with menstruation is also closely tied to economics in the ways in which its impact plays out for Pakistani women, suggests Amjad.

“In most households, it’s the men who make financial decisions,” she says. “Even if the woman is bringing the money, she’s giving it to the man, and he is deciding where that money needs to go.”

And if the cost of women’s health feels too high, that’s often compromised. “[With] the inflated prices due to the tax, there is no conversation in many houses about whether we should buy pads,” she says. “It’s an expense they cannot afford organically.”

According to the 2023 study in the Frontiers in Public Health, over half of Pakistani women are not able to afford sanitary pads.

If the taxes are removed, and menstrual hygiene becomes more affordable, the benefits will extend beyond health, says Amjad.

School attendance rates for girls could improve, she said. Currently, more than half of Pakistan’s girls in the five to 16 age group are not in school, according to the United Nations. “We will have stress-free women. We will have happier and healthier women.”

Lawyer Ahsan Jehangir Khan, the co-petitioner with Mahnoor Omer, in the case demanding an end to the 'period tax'. [Photo courtesy Ahsan Jehangir Khan]
Lawyer Ahsan Jehangir Khan, the co-petitioner with Mahnoor Omer, in the case demanding an end to the ‘period tax’ [Photo courtesy of Ahsan Jehangir Khan]

‘Feeling of justice’

Omer says her interest in women’s and minority rights began early. “What inspired me was just seeing the blatant mistreatment every day,” she says. “The economic, physical, and verbal exploitation that women face, whether it’s on the streets, in the media, or inside homes, never sat right with me.”

She credits her mother for making her grow up to be an empathetic and understanding person.

After completing school, she worked as a gender and criminal justice consultant at Crossroads Consultants, a Pakistan-based firm that collaborates with NGOs and development partners on gender and criminal justice reform. At the age of 19, she also volunteered at Aurat March, an annual women’s rights movement and protest held across Pakistan on International Women’s Day – it’s a commitment she has kept up since then.

Her first step into activism came at 16, when she and her friends started putting together “dignity kits”, small care packages for women in low-income neighbourhoods of Islamabad. “We would raise funds with bake sales or use our own money,” she recalls.

The money she was able to raise enabled her to distribute about 300 dignity kits that she and her friends made themselves. They each contained pads, underwear, pain medication and wipes. But she wanted to do more.

She got a chance when she started working at the Supreme Court in early 2025, first as a law clerk. She’s currently pursuing postgraduate studies in gender, peace and security at the London School of Economics and says that she will go back to Pakistan to resume her practice after she graduates.

She became friends with fellow lawyer Ahsan Jehangir Khan, who specialises in taxation and constitutional law. The plan to challenge the “period tax” emerged from their conversations.

“He pushed me to file this petition and try to get justice instead of just sitting around.”

Khan, who is a co-petitioner in the case, says that fighting the taxes is about more than accessibility and affordability of sanitary pads – it’s about justice. “It’s a tax on a biological function,” he says.

Tax policies in Pakistan, he says, are written by “a privileged elite, mostly men who have never had to think about what this tax means for ordinary women”. The constitution, he adds, “is very clear that you cannot have anything discriminatory against any gender whatsoever”.

To Amjad, the Dastak Foundation founder, the fight for menstrual hygiene is closely tied to her other passion – the struggle against climate change. The extreme weather-related crisis, such as floods, that Pakistan has faced in recent times, she says, hit women particularly hard.

She remembers the trauma many women she worked with after the 2022 floods described to her. “Imagine that you are living in a tent and you have mahwari [menstruation] for the first time,” she says. “You are not mentally prepared for it. You are running for your life. You don’t have access to safety or security. That trauma is a trauma for life.”

As temperatures rise on average, women will need to change sanitary pads more frequently during their periods – and a lack of adequate access will prove an even bigger problem, Amjad warns. She supports the withdrawal of taxes on sanitary pads – but only those made from cotton, not plastic ones that “take thousands of years to decompose”.

Amjad is also campaigning for paid menstruation leave. “I have come across women who were fired because they had pain during periods and couldn’t work,” she says. “When you are menstruating, one part of your brain is on menstruation. You can’t really focus properly.”

Meanwhile, opponents of the taxes are hoping that Omer’s petition will pressure the Pakistani government to follow other nations such as India, Nepal and the United Kingdom that have abolished their period taxes.

Taking on that mantle against the government’s policies didn’t come easily to Omer. Her parents, she says, were nervous at first about their daughter going to court against the government. “They said it’s never a good idea to take on the state,” she says.

Now, they’re proud of her, she says. “They understand why this matters.”

To her, the case is not just a legal fight. “When I think of this case, the picture that comes to mind … It’s not a courtroom, it’s a feeling of justice,” she says. “It makes me feel a sense of pride to be able to do this and take this step without fear.”

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EU does not support loan of frozen Russian funds

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EU leaders agreed to help support Ukraine’s “financial needs” for the next two years on Thursday night – but stopped short of releasing billions of euros in frozen Russian cash to help fund the country’s defence.

A decision to use €140bn (£122bn) in Russian assets held in a Belgian clearing house was pushed back until December after concerns were raised by Belgium.

The controversial move would be on top of sanctions the block has imposed on Russia – the latest on Thursday targeting the Kremlin’s oil revenues.

The Brussels meeting came ahead of a London summit on Friday, where Prime Minister Sir Keir Starmer will urge European leaders to boost long-range missile supplies to Kyiv.

Ukrainian President Volodymyr Zelensky is set to attend the meeting of the so-called “coalition of the willing”, along with Nato Secretary General Mark Rutte, Denmark’s Prime Minister Mette Frederiksen and Netherlands’ Dick Schoof. Other leaders including French President Emmanuel Macron will join virtually.

On Thursday, European ministers held talks in Brussels about how billions of euros worth of frozen Russian cash could be made available to Ukraine as a so-called “reparations loan”.

Many EU governments had hoped the leaders would back the plan and request the European Commission, the EU’s executive body, to work out a formal legal proposal in the coming weeks.

But the final text, adopted after marathon talks, stopped short of greenlighting plans. Instead, it asked the Commission for “options for financial support based on an assessment of Ukraine’s financing needs”.

“Russia’s assets should remain immobilised until Russia ceases its war of aggression against Ukraine and compensates it for the damage caused by its war,” the declaration added.

The aim is now for EU leaders to reach a deal in December.

“This is a topic that is certainly not trivial. It’s very complex,” European Commission President Ursula von der Leyen said after the summit. “It was also very clear there are points to be clarified.”

Antonio Costa, European Council President, sounded a positive note, saying the bloc had “committed to ensure that Ukraine’s financial needs will be covered for the next two years”.

“Russia should take good note of this: Ukraine will have the financial resources it needs to defend itself,” he told a news conference.

Zelensky, who was in Brussels for the summit, welcomed the outcome as a signal of “political support” for the notion of using Russian assets to keep Kyiv in the fight.

There are a number of legal complexities surrounding using Russia’s money.

Belgium, in particular, has been reluctant to back using the frozen assets, as it is nervous about having to shoulder any potential consequences should Russia legally challenge Euroclear, the clearing house where the money is located.

Belgian Prime Minister Bart De Wever said his country needed concrete and solid guarantees before supporting the plan, pointing out the plan was “unchartered territory”.

The Belgian government has argued it could expose Euroclear to litigation and ultimately create a major financial crisis.

“Can this (plan) be legal? That is a very good question … There are no clear answers,” De Wever said.

“We will in any case be buried in litigation. That seems like a certainty.”

Russia has criticised the EU’s proposals.

“Any confiscatory initiatives from Brussels will inevitably result in a painful response,” said Russian foreign ministry spokeswoman Maria Zakharova.

The EU’s latest sanctions followed US measures against Russia’s oil industry – the first time Donald Trump has sanctioned Moscow as he grows frustrated over Vladimir Putin’s refusal to end the war.

After the US sanctions were announced on Wednesday evening, Trump confirmed that a planned meeting with the Russian president in Budapest had been shelved indefinitely.

“Every time I speak to Vladimir, I have good conversations and then they don’t go anywhere,” he said.

The US sanctions targeted Russia’s oil giants Rosneft and Lukoil. In response, Putin said the “unfriendly” US measures “will have certain consequences, but they will not significantly affect our economic well-being”.

Oil is one of Russia’s biggest exports. Ukraine wants to use long-range missiles to target Russian oil and energy plants.

Zelensky had hoped to secure Tomahawk cruise missiles from the US but last week Trump refused the request because the weapons are “highly complex” and take a year of intense training to use.

The EU’s latest punitive measures against Russia targeted three Chinese businesses, including two oil refineries and an energy trader, that are “significant buyers of Russian crude oil”.

The measures are “meant to deprive Russia of the means to fund this war,” said Kallas as well as send a message, specifically that “Russia can’t outlast us,” she said.

China condemned the decision, which a commerce ministry spokesperson said “seriously undermined the overall framework of China–EU economic and trade co-operation”.

IMF warns that strengthening dollar could challenge Asia’s resilience to tariffs

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Reversal of weak dollar may test Asia's resilience to tariffs, IMF says

Donald Trump reverses decision to increase military presence in San Francisco | Latest News on Donald Trump

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For weeks, President Donald Trump had been threatening to deploy members of the United States military to San Francisco, California.

But on Thursday, Trump made a sudden about-face, announcing he would not push forward with a “surge” of troops to the Democratic stronghold – at least, for now.

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“The Federal Government was preparing to ‘surge’ San Francisco, California, on Saturday, but friends of mine who live in the area called last night to ask me not to go forward with the surge,” Trump wrote on his online platform, Truth Social.

The Republican leader credited Nvidia CEO Jensen Huang and Salesforce cofounder Marc Benioff, two titans of the tech industry, with helping to convince him to reverse course.

Trump added that he had also spoken with San Francisco’s mayor, centrist Democrat Daniel Lurie. But in relaying their call, the president hinted that Thursday’s decision may not be his final word on the matter.

“He asked, very nicely, that I give him a chance to see if he can turn it around,” Trump said of Lurie in his post.

“I told him I think he is making a mistake, because we can do it much faster, and remove the criminals that the Law does not permit him to remove. I told him, ‘It’s an easier process if we do it, faster, stronger, and safer but, let’s see how you do?’”

San Francisco Mayor Daniel Lurie discusses President Donald Trump’s comments on October 23 in San Francisco [Noah Berger/AP Photo]

‘Cruel, un-American tactics’

Since taking office for a second term in January, Trump has led a campaign of mass deportation that has prompted protests and concerns about human rights violations.

Trump has answered those protests, in part, by sending National Guard troops to major cities with the stated aim of protecting federal immigration agents.

But critics, including California Governor Gavin Newsom, have repeatedly warned that the military deployments not only ratchet up tensions but run afoul of the law.

Lurie, one of the heirs to the Levi Strauss jeans company fortune, was among those critics.

On Wednesday, bracing for an impending deployment, the mayor gave a news conference surrounded by city officials, calling on the residents of San Francisco to stand united.

“We have already seen this federal administration deploy cruel, un-American tactics to target immigrant communities in our city. If we see these kinds of tactics used again or escalated, we will protest,” Lurie said.

He emphasised that local law enforcement would not assist federal forces in carrying out immigration raids.

“San Francisco will never stand by as our neighbours are targeted, and neither will I,” Lurie continued.

The state government of California, meanwhile, had warned earlier in the week that it was prepared to sue as soon as any federalised National Guard troops arrived in San Francisco.

The Posse Comitatus Act, it pointed out, expressly prohibits federal troops from acting as civilian law enforcement, unless called upon by the state.

In a statement, Governor Newsom, who is considered a leading Democratic contender in the next presidential race, compared Trump’s actions to those of a “wannabe tyrant”.

“The notion that the federal government can deploy troops into our cities with no justification grounded in reality, no oversight, no accountability, no respect for state sovereignty – it’s a direct assault on the rule of law,” Newsom said.

A US Border Patrol agent tries to clear protesters away from a car entering a Coast Guard facility
A US Border Patrol officer tries to clear protesters as a vehicle enters the US Coast Guard Base in Alameda, California, on October 23 [Noah Berger/AP Photo]

Series of crackdowns

But despite outcry from states like California and Illinois, Trump has pushed ahead with National Guard deployments, leading to a spate of lawsuits.

California continues to be embroiled in a legal fight over Trump’s decision to send troops to Los Angeles in June, when the city convulsed with protests and outrage over immigration raids at workplaces, shopping centres and parks.

Demonstrations, the majority of them peaceful, spilled into the streets. Trump nevertheless accused protesters of being violent and sent as many as 4,000 members of the California National Guard to the city, over Newsom’s opposition.

While Newsom has argued that the deployment was a violation of the Posse Comitatus Act, the Trump administration has cited lines from the US Code as justification.

The US Code allows for the federalisation of state National Guard troops if there is the threat of invasion or rebellion, or if the federal government is unable to otherwise carry out its laws.

Though the Los Angeles protests have largely subsided, the Trump administration has proceeded to send National Guard troops to other Democrat-led jurisdictions, despite pushback from local leaders.

Earlier this month, for instance, Trump authorised the National Guard to go to Chicago, Illinois, prompting a lawsuit from that state.

And in late September, the president announced on Truth Social he would send troops to “war-ravaged” Portland, Oregon, a move that was blocked by an emergency court petition.

Meanwhile, Trump has touted the benefits of military deployments to Washington, DC, and Memphis, Tennessee, arguing that the presence of the troops lowered crime in both cities.

Marc Benioff
Salesforce cofounder Marc Benioff faced criticism for calling for a National Guard deployment in San Francisco [Darron Cummings/AP Photo]

San Francisco on the radar

As a longtime left-wing bastion, San Francisco has long been a punching bag for Trump and other Republicans.

Even on the campaign trail, the president took shots at the city’s Democratic leadership, blaming it for San Francisco’s “destruction”.

But in recent weeks, Trump closed in on the city as the subject of his next crime and immigration crackdown.

“We’re going to go in San Francisco,” Trump told Fox News on October 19. “San Francisco was truly one of the great cities of the world. And then, 15 years ago, it went wrong. It went woke.”

Trump’s decision to reverse course on Thursday mirrored that of one of his supporters, Marc Benioff.

The billionaire’s software company, Salesforce, is based in San Francisco, and Benioff holds a weekend-long tech conference in the city every year.

But on the eve of this year’s event, Benioff told The New York Times that he would welcome the National Guard in San Francisco, echoing Republican calls to “clean” up the city.

“We don’t have enough cops, so if they can be cops, I’m all for it,” Benioff said.

Those comments drew instant backlash from city officials, and comedians slated to perform at his annual conference dropped out. Days later, Benioff took to social media to apologise for his comments.

“I do not believe the National Guard is needed to address safety in San Francisco,” Benioff wrote, citing his conversations with locals.

“My earlier comment came from an abundance of caution around the event, and I sincerely apologize for the concern it caused.”

Benioff was among the advisers Trump cited as an influence in Thursday’s decision to back down from his long-threatened deployment.

Already, protests had erupted outside the US Coast Guard facility in Alameda, part of the San Francisco Bay Area.

For his part, Mayor Lurie said he would welcome “continued partnerships” with the Federal Bureau of Investigation (FBI) or the Drug Enforcement Agency (DEA) as the city struggles to reduce accidental overdoses.

But, Lurie added, that invitation did not include military involvement.

“Having the military and militarized immigration enforcement in our city will hinder our recovery,” he said in a statement.

Ex-BLS Chief Cautions Powell Is Operating Without Clear Vision During Critical Fed Period

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The Federal Reserve faces an unprecedented challenge as it prepares to set interest rates next week—making its decision with almost no economic data available.

The government shutdown has halted the release of most U.S. economic statistics, including the monthly jobs report. However, the Fed also recently lost access to one of its main private sources of backup data. 

Payroll-processing giant ADP quietly stopped sharing its internal data with the central bank in late August, leaving Fed economists without a real-time measure that had covered about one-fifth of the nation’s private workforce. For years, the feed had served as a real-time check on job-market conditions between the Bureau of Labor Statistics’ monthly reports. Its sudden disappearance, first reported by the Wall Street Journal, could leave the Fed “flying blind,” former Bureau of Labor Statistics commissioner Erica Groshen said.

Groshen told Fortune that, in her decades working at the BLS and inside the Fed, the loss of ADP data is “very concerning for monetary policy.”

The economist warned that at a moment when policymakers are already navigating a fragile economy—Fed Chair Jerome Powell has said multiple times that there is no current “risk-free path” to avoid recession or stagflation—the data blackout raises the risk of serious missteps. 

“The Fed could overtighten or under-tighten,” Groshen said. “Those actions are often taken too little and too late, but with less information, they’d be even more likely to be taken too little too late.” 

Rupture after years of collaboration

Since at least 2018, ADP has provided anonymized payroll and earnings data to the Fed for free, allowing staff economists to construct a weekly measure of employment trends. The partnership is well-known to both Fed insiders and casual market watchers. However, according to The American Prospect, ADP suspended access shortly after Fed Governor Christopher Waller cited the data in an Aug. 28 speech about the cooling labor market.

Powell has since asked ADP to restore the arrangement, according to The American Prospect

Representatives at ADP did not respond to Fortune’s request for comment. The Fed declined to comment.

Groshen said there are several plausible reasons why ADP might have pulled the plug. One possibility, she said, is that the company found a methodological issue in its data and wanted to fix it before continuing to share information used in monetary policy. 

“That would actually be a responsible decision,” she told Fortune, noting that private firms have more flexibility than federal agencies but less institutional obligation to be transparent about errors.

Another explanation, Groshen said, could be internal or reputational pressure. After Waller mentioned the collaboration publicly, ADP may have worried about how it looked to clients or shareholders. 

“You could imagine investors saying, ‘Why are we giving this away for free? The Fed has money,’” she said. The company might also have wanted to avoid being seen as influencing central-bank decisions, especially in a politically charged environment.

Whatever the motivation, Groshen said the episode underscores how fragile public-private data relationships remain. Without clear frameworks or long-term agreements, companies can withdraw at any time.

“If policymakers build systems around data that can vanish overnight,” she said, “that’s a real vulnerability for economic governance.”

A data blackout at a critical moment

The timing could hardly be worse. 

On Thursday next week, the Federal Open Market Committee meets to decide whether to lower interest rates again, following a long-awaited quarter-point cut in September. With the BLS pausing most releases under its shutdown contingency plan, official figures on employment, joblessness, and wages have been delayed—starting with the September report and possibly extending into October.

In the absence of real-time data, Fed economists are relying on a patchwork of alternatives: state unemployment filings, regional bank surveys, and anecdotal reports from business contacts. Groshen called those “useful but incomplete,” adding that the lack of consistent statistical baselines makes monetary policy far more error-prone.

She advocated for the BLS to receive “multiyear funding” from Congress so that it could stay open even during government shutdowns. 

“I hope that one silver lining to all these difficulties will be a realization on the part of all the stakeholders, including Congress and the public, that our statistical system is essential infrastructure that needs some loving care at the moment,” Groshen said.

Our Knowledge of the NBA Gambling and Rigged Poker Game Arrests

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Getty Images Terry Rozier #2 of the Miami Heat dribbles the ball during the second half in a preseason game against the Memphis Grizzlies at Kaseya Center on October 17, 2025 in Miami, Florida. Getty Images

Terry Rozier of the Miami Heat is among those who were arrested as part of a multi-year investigation into alleged fraud involving NBA players and organised crime.

US authorities announced several high-profile arrests on Thursday, including of a star player and a coach in the National Basketball Association (NBA), for alleged illegal sports betting.

Among those in custody are Portland Trail Blazers coach Chauncey Billups and Miami Heat player Terry Rozier, both of whom were reportedly arrested after their teams’ games on Wednesday.

The arrests are part of a sweeping investigation into illegal gambling that produced two indictments, the FBI said — one into players who are allegedly faking injuries to influence betting odds, and another involving an illegal poker ring tied to organised crime.

Here is what we know about the cases.

What are the allegations?

FBI Director Kash Patel described the allegations to reporters as “mind-boggling”.

They include indictments in two major cases, officials said, both involving fraud.

The first case is called “operation nothing but bet,” in which players and associates allegedly used insider information to manipulate wagers on major sports betting platforms.

In some cases, players altered their performance or took themselves out of games to ensure those bets were paid out, according to New York City police commissioner Jessica Tisch. Those bets amounted to tens of thousands of dollars in profits.

The second case is more complex in nature, officials said, and involved four of the five major crime families in New York as well as professional athletes.

The accused in that case are alleged to have participated in a scheme to rig illegal poker games and steal millions of dollars.

They did so using “very sophisticated” technology including off-the-shelf shuffling machines, special contact lenses and eye glasses to read pre-marked cards, according to authorities. They also used an X-ray table that could read cards that were face down.

The victims were allegedly lured to play in these games with former professional athletes, who acted as “face cards” in the scheme. The victims were unaware that everyone, including the dealer and the other players, were in on the scam.

Authorities said they began probing these poker games in 2019, spanning multiple locations including the Hamptons, Las Vegas, Miami and Manhattan.

The accused allegedly laundered profits via bank wires and crypto currencies.

They are also alleged to have committed acts of violence, including a robbery at gunpoint and extortion against victims.

Both schemes amounted to tens of millions of dollars in theft and robbery across several years and 11 states, authorities said.

Which players have been arrested?

All in all, authorities say 34 defendants were indicted on charges related to the two fraud cases.

Six were charged in the first case of players allegedly faking injuries to influence betting odds, including Miami Heat player Rozier.

New York police commissioner Jessica Tisch said that in March 2023, Rozier, then playing for the Charlotte Hornets, allegedly let others close to him know that he planned to leave a game early with a supposed injury.

Members of the group then used that information to place fraudulent bets and cash out big, she said.

Commissioner Tisch said on Thursday after Rozier’s arrest that his “career is already benched, not for injury but for integrity”.

Former NBA player Damon Jones was also arrested. He is said to have been involved in two games that were allegedly part of the scheme, when the Los Angeles Lakers met the Milwaukee Bucks in February 2023, and a January 2024 game between the Lakers and Oklahoma City Thunder.

Authorities identified a total of seven NBA games between February 2023 and March 2024 that were part of the case:

  • 9 February, 2023 – Los Angeles Lakers v Milwaukee Bucks
  • 23 March, 2023 – Charlotte Hornets v New Orleans Pelicans
  • 24 March, 2023 – Portland Trail Blazers v Chicago Bulls
  • 6 April, 2023 – Orlando Magic v Cleveland Cavaliers
  • 15 January, 2024 – Los Angeles Lakers v Oklahoma City Thunder
  • 26 January, 2024 – Toronto Raptors v Los Angeles Clippers
  • 20 March, 2024 – Toronto Raptors v Sacramento Kings

The second case related to illegal poker games involved a total of 31 defendants, including Portland Trail Blazers coach Billups, who was inducted into the basketball Hall of Fame last year.

Authorities said three of the accused were charged in both cases.

Thirteen members and associates of the Bonanno, Genovese and Gambino crime families in New York were also indicted in the illegal poker case.

The charges include robbery, extortion, wire fraud, bank fraud and illegal gambling.

The defendants have been arrested and are due to appear in court later on Thursday, authorities said. They are expected to be arraigned in a Brooklyn, New York, court at a later date.

What has the NBA said about the allegations?

In a statement on Thursday, the NBA said it is in the process of reviewing the federal indictments that were announced and that it is co-operating with authorities.

The league added that Rozier and Billups are being placed “on immediate leave” from their teams.

“We take these allegations with the utmost seriousness, and the integrity of our game remains our top priority,” the statement said.

Who are New York’s notorious ‘Five Families’?

Authorities said the alleged scheme involved four of the five well-known crime families of New York.

The Five Families – the Bonanno, Colombo, Gambino, Genovese and Lucchese – have ruled the city’s Italian American mafia since 1931.

Major mob takedowns reduced the prevalence of mafia activity in the 1990s, aided by the Racketeer Influenced and Corrupt Organizations (RICO) Act and then-New York mayor Rudy Giuliani.

But, as Thursday’s indictments show, the mafia has not entirely gone away.

The Five Families are part of the larger American-Sicilian mafia operation known as La Cosa Nostra, which translates to “this thing of ours”, and the members often work closely with their counterparts in Sicily.

On the Italian side, the gangsters consider New York City to be a “gym” where their members go to be toughened up, criminology professor and modern organised crime expert Anna Sergi, previously told BBC.

Deezer confirms subscriber growth momentum in France, reports Q3 revenues of $153m

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Deezer has reported Q3 2025 revenues of €131.4 million ($153.5 million), down 1.1% year-on-year at constant currency, as growth in its Direct subscriber business offset an anticipated decline in its Partnerships segment.

The French streaming company also confirmed its full-year guidance, expecting flat to slightly declining revenues YoY, while projecting positive adjusted EBITDA in H2 and positive free cash flow for the full year.

Deezer splits its revenues into three segments: ‘Direct’; ‘Partnerships’; and ‘Other’.

The company reported that its Direct segment was supported by “sustained subscriber momentum,” with its Direct subscriber base growing 9.7% YoY to 5.5 million at the end of Q3.

Direct revenues reached €87.9 million ($102.7m) in Q3 2025, up 3.1% YoY at constant currency compared to €85.8 million in Q3 2024.

The company said this revenue growth was driven by “strong momentum in France” with its subscriber base in its home market increasing to 3.7 million (up 11.7% YoY on a like-for-like basis), reflecting what Deezer called the success of its family offers.

Deezer’s total subscriber base at the end of Q3 across the ‘Direct’ and ‘Partnerships’ segments stood at 9 million, down 6.7% YoY.



The company noted that subscriber growth in France has accelerated for three consecutive quarters, rising from 6.4% YoY growth at the end of Q1, to 8.3% at the end of Q2, and 11.7% at the end of Q3.

Direct subscribers in the ‘Rest of World’ reached 1.8 million, up 6.1% YoY on a like-for-like basis, which Deezer attributed to its “growing brand appeal, product innovation and stance on transparency and fairness in the music industry.”



Partnerships revenue amounted to €35.6 million ($41.6m) in Q3 2025, down 13.2% YoY at constant currency from €41.5 million in Q3 2024.

The company said this decline “mainly reflected the residual impact of the Mercado Libre model shift,”  referring to the conversion of promotional subscription cohorts to full-price premium offers, partly offset by contributions from RTL+ and other recent partnerships.

Partnerships subscribers stood at 3.5 million at the end of Q3, compared to 4.7 million in Q3 2024, representing a 24.5% YoY decline.

However, ARPU in the Partnerships segment rose 11.2% YoY to €3.2, which Deezer attributed to “a better mix” as it focuses on higher-value partnerships.



Other revenue, which comprises advertising and ancillary revenue, amounted to €7.9 million ($9.2m) in Q3 2025, up 20.5% YoY at constant currency from €6.7 million in Q3 2024.

Deezer said this growth “mainly reflected the performance of the white labelling solutions for hardware/media partners.”

“Subscriber growth in France has accelerated for a third consecutive quarter, confirming the positive impact of our differentiation initiatives.”

Alexis Lanternier, Deezer

Alexis Lanternier, CEO of Deezer, said: “Subscriber growth in France has accelerated for a third consecutive quarter, confirming the positive impact of our differentiation initiatives in our home market.

“In the rest of the world, subscription numbers in the Direct segment are also picking up pace, reflecting the quality of our service and the appeal of our brand as we champion transparency and fairness in music streaming.”

He added that Deezer’s AI detection system and new personalization features are “attracting global attention, opening opportunities beyond our core markets,” and that the company is “leading the way in protecting artists and rights holders, while delivering innovative, unforgettable music experiences for fans.”

Last month, Deezer reported that fully AI-generated music now constitutes 28% of all tracks delivered to its platform each day.

Deezer said that it now receives over 30,000 fully AI-generated tracks daily, marking a sharp increase from the 20,000 figure it reported in April and the 10,000 it disclosed in January when it first launched its proprietary AI detection tool.

According to the platform, up to 70% of plays for these fully AI-generated tracks have been detected as fraudulent, with the company filtering these streams out of royalty payments.

Although fully AI-generated music currently accounts for only around 0.5% of all streams on Deezer, the platform believes the primary purpose of uploading these tracks is fraudulent activity rather than genuine creative expression.

The company rolled out an AI tagging system to fight streaming fraud in June.


Elsewhere, Deezer noted that it recently announced the launch of universal sharing for playlists, following the introduction of universal sharing for individual songs in April 2025.

The feature enables users to share Deezer playlists that can be opened on Spotify, Apple Music and YouTube Music. Using automatic song recognition technology, Deezer identifies equivalent tracks across platforms and redirects users to the appropriate version of each song.

The company also highlighted its partnership diversification efforts, including deals with Norlys in Denmark, Fitness Park and Molotov TV in France, and opportunities through Deezer for Business.

In Brazil, Deezer has entered an exclusive agreement with Azerion, a digital entertainment and media platform, for audio and video monetization. The partnership includes a direct integration with Hawk, Azerion’s demand-side platform.


EUR to USD conversions in this report have been made at the average rate for the period according to the European Central BankMusic Business Worldwide