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Implant Provides Potential Treatment for Corneal Blindness

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A tiny implant that beams images straight to the retina, bypassing a damaged cornea altogether, could give sight back to millions living with corneal blindness – no donor tissue required. Human trials may be underway in as little as two years.

The cornea is the most frequently transplanted human tissue. For the millions of people living with corneal blindness, the transplantation of donor tissue has long been the only real hope they have for regaining vision. But even when transplants are possible, many patients remain legally blind.

Now, researchers have unveiled a futuristic workaround: an implant that sidesteps the damaged cornea entirely, projecting images straight onto the retina. Dubai-based deep-tech company Xpanceo and Italian startup Intra-Ker have announced the first successful proof-of-concept for their intracorneal implant.

“With over 12 million people awaiting corneal transplants, we see this as the beginning of a new era, where advanced optics and computation can bridge longstanding gaps in vision care,” said Xpanceo founder, Dr Valentyn Volkov.

Normally, light passes through a transparent cornea before reaching the retina. If the cornea is scarred or clouded, no amount of healthy retinal tissue matters – the brain never gets the signal. Instead of trying to biologically repair the cornea, this implant reimagines the problem as one of data delivery.

External smart glasses, fitted with a camera, capture the visual scene. This is wirelessly transmitted, using the same communication and power system designed for Xpanceo’s smart contact lenses, to a 450×450-pixel microdisplay sealed inside the eye. That display then beams the visual data directly to the retina, bypassing the cornea altogether.

“Until now, implanting electronics in the anterior segment of the eye has not met with success,” said Professor Massimo Busin, President and CEO of Intra-Ker. ”With only 185,000 traditional corneal transplants performed each year, we see a critical need for solutions that don’t rely on donor tissue. This system is made possible by our IP-protected technology, which enables precise and safe implantation of sealed electronic components using a procedure no more complex than standard corneal surgery.”

The grayscale image (left) shows the laptop screen displaying a real-time video signal from the donor eye’s retina
The grayscale image (left) shows the laptop screen displaying a real-time video signal from the donor eye’s retina

Mindset Consulting

“The initial proof of concept combined a 450×450 pixel display with our micro-optical projection system into a 5.6-mm package, and for clinical use, we aim to miniaturize the entire system,” Volkov added.

Human trials could begin within two years, with a projected addressable market of US$50 million to $200 million annually. If successful, the device could offer new independence to millions of people who are effectively shut out of donor-based sight-restoration solutions, bringing an engineered alternative to one of the world’s most common causes of blindness.

Source: Intra-Ker, Xpanceo

Northern India Devastated by Deadly Floods

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Heavy rains, flash-floods and cloudbursts have battered much of Northern India in recent weeks, killings hundreds of people and displacing more than a million.

Insights into Zymeworks’ Strategic Pipeline Shared at Wells Fargo Conference

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Zymeworks at Wells Fargo Conference: Strategic Pipeline Insights

Rights groups in Palestine face US sanctions for backing ICC investigation into Israel | Latest developments in Israel-Palestine conflict

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Al-Haq, Palestinian Centre for Human Rights (PCHR) and Al-Mezan targeted for engaging with ICC, state department says.

The United States has added three prominent Palestinian rights groups, Al-Haq, Palestinian Centre for Human Rights (PCHR) and Al-Mezan Center for Human Rights to its sanctions list.

The groups were added to the Department of the Treasury’s “Specially Designated Nationals and Blocked Persons List” on Thursday.

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In a subsequent statement, US Secretary of State Marco Rubio said the rights groups were targeted for having “directly engaged in efforts by the International Criminal Court (ICC) to investigate, arrest, detain, or prosecute Israeli nationals, without Israel’s consent”.

The Trump administration had previously sanctioned the ICC in response to its investigation and subsequent arrest warrants issued for Israeli Prime Minister Benjamin Netanyahu and former Israeli Defence Minister Yoav Gallant for alleged war crimes committed in Gaza.

All three groups had provided evidence on Israeli abuses in the case.

“The United States will continue to respond with significant and tangible consequences to protect our troops, our sovereignty, and our allies from the ICC’s disregard for sovereignty, and to punish entities that are complicit in its overreach,” Rubio said.

The Ramallah-based Al-Haq has been a leading organisation both in the occupied Palestinian territory and internationally seeking accountability for Israeli abuses, while leading litigation in several countries.

The Gaza City-based Palestinian Centre for Human Rights and the Al-Mezan Center for Human Rights have been leading independent organisation that have documented Israel’s ongoing war in Gaza.

In a statement shared by all three organisations, they condemned “in the strongest terms the draconian sanctions” imposed by the Trump administration.

“These measures in times of live genocide against our People, is a coward[ly], immoral, illegal and undemocratic act,” the statement said.

“Only states with complete disregard to international law and our shared humanity can take such heinous measures against human rights orgs working to end a genocide,” the statement said.

In a post on the social media platform X, Mohsen Farshneshani, a sanctions lawyer and advisor at Democracy for the Arab World Now (DAWN), described the organisations as “three of the most prominent Palestinian human rights groups”.

“Shameful but not surprising,” Farshneshani wrote. “This administration bends over backwards to put Israel First every time.”

The US previously sanctioned the Ramallah-based Addameer, a human rights organisation focused on Palestinian prisoners and detainees, in June.

At the time, Amnesty International and Human Rights Watch, which both work closely with the group, said the sanctions “would make day-to-day operations harder and harder, including for their employees, assisted communities and service suppliers. This will also negatively affect their engagement with their partner organizations, locally and internationally, including US-based groups”.

“The US is using its sanctions regime to do the bidding of the Israeli government, which has long systematically sought to muzzle human rights reporting and advocacy,” it added.

In July, the Trump administration also sanctioned the Palestinian Authority (PA), which administers the occupied West Bank, and the Palestine Liberation Organization (PLO), which represents Palestinians internationally.

At the same time, the Trump administration has revoked sanctions imposed under former US President Joe Biden on Israelis from illegal settlements and organisations accused of violence.

Law enforcement officials conducted a raid on Streameast’s offices and successfully dismantled the largest illegal sports streaming platform, which had garnered over 1.6 billion visits in the previous year.

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You’ll have to just imagine the casino pop-up ads in the middle of a naked bootleg play now. The Alliance for Creativity and Entertainment (ACE) announced yesterday that the largest illegal sports streaming platform, Streameast, is dead…just in time for the NFL 2025 season kickoff today.

It garnered over 1.6 billion visits in the last year and averaged roughly 136 million monthly visits, according to ACE. The coalition said it worked with Egyptian authorities to shut down Streameast and its 80 associated domains:

  • The network illegally streamed a huge range of matches and games from Europe’s Premier League and Champions League, as well as those from the NFL, NBA, and MLB.
  • Streameast also showed pirated F1 races, MMA fights, and boxing matches.

Authorities raided Streameast’s offices and took three laptops, four smartphones, $123,000 in Visa cards, and roughly $200,000 in crypto wallets.

Maybe you would steal a car. It’s hard to slap a number on just how much digital piracy costs broadcast companies, but one 2025 survey from Brand Finance found that 43% of 14,000 people in 13 countries considered using an unofficial streaming service to watch games. A 2023 study from YouGov found that 11% of adults did actually pirate content in the last year, with about half of them saying they’d done so because the cost was otherwise too high.—MM

This report was originally published by Morning Brew.

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What we understand about the fatal accident

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Emily Atkinson, Malu Cursino & Patrick JacksonBBC News

Watch: Emergency crews surround derailed Portugal funicular

A carriage on one of Lisbon’s most iconic tourist attractions, the Glória funicular railway derailed and crashed on Wednesday. The popular tram-like form of transport is designed to travel up and down steep slopes.

Portuguese authorities have confirmed 16 people were killed, revising an earlier figure which put the death toll at 17.

It is not yet clear what caused the carriage to derail, but local media reports say a cable fault is suspected.

An investigation into the cause of the accident is under way.

Here is everything we know so far.

A satellite map of central Lisbon shows the location of where Lisbon's Gloria funicular crashed. Labels show the crash happened to the right of Rossio train station, close to Restauradores square and Avenida da Liberdade. An inset shows the hill in which the crash happened, showing a steep gradient.

What happened?

The carriage derailed at around 18:15 (17:15 GMT) on Wednesday 3 September, near the city’s Avenida da Liberdade boulevard.

More than 60 rescue personnel and 22 vehicles were deployed to the scene.

Officials say it is too early to determine what caused the crash, but Portuguese newspaper Observador reports that a cable came loose along the railway’s route, causing it to lose control and collide with a building.

As smoke engulfed the area, people could be seen running away from the scene.

Images and footage show an overturned, crumpled yellow carriage lying on the cobblestone street, surrounded by emergency responders.

Some people were trapped in the wreckage, and had to be freed by emergency workers.

Tour guide Marianna Figueiredo witnessed the crash and was amongst those who tried to rescue people.

“People started to jump from the windows inside the funicular at the bottom of the hill,” she told the BBC.

“Then I saw another one [further up] that was already crushed. I started to climb the hill to help the people but when I got there the only thing I could hear was silence.”

She said what she witnessed yesterday evening was “very difficult to describe”. “It was very bad. A big tragedy.”

Who are the casualties?

Emergency services gave a death toll of 17 on Thursday but Prime Minister Luís Montenegro later said 16 were dead.

Reports in Portugal have attributed the mistake in the death toll to a duplicate registration of a victim at one hospital.

Exact information on who was riding the funicular at the time – and who may have been injured on the street – remains unclear but at least 20 people have been injured.

Those taken to hospital include four Portuguese, two Germans, two Spaniards, one Cape Verdean, one Canadian, one Italian, one French person, one Swiss, one Moroccan and one Korean, the city’s Municipal Civil Protection Service was quoted as saying by Portugal’s Lusa news agency.

André Jorge Gonçalves Marques, an employee of the city’s public transport operator, Carris, is among the dead.

“In his 15 years with Carris, he performed his duties with excellency,” the company said.

Portuguese media is reporting that a three-year-old child is being treated in one of Lisbon’s hospitals, while the child’s mother, who is pregnant, has been transferred to a maternity unit.

The Glória funicular can carry about 40 passengers and is extremely popular with tourists but it is also crucial for the city’s residents, to help them travel up and down Lisbon’s hilly streets.

It is not known how many people were onboard at the time of the crash, however.

What is the Glória funicular and how does it work?

Two yellow funicular carriages on a steep 18% incline in Lisbon, connected by an underground cable. Overhead power lines and tracks are labelled. The brakeman is visible in the carriage on the left, which is descending. A person walks uphill beside the carriage on the right.

A funicular is a type of railway system that allows travel up and down steep slopes, and in Lisbon, they are a crucial means of navigating the city’s steep, cobbled streets.

The city’s funicular railways – Glória, Lavra, Bica and Graça – are a popular tourist attraction, as the bright yellow tram-like vehicles snake through the often-narrow, hilly streets.

Glória was opened in 1885 and electrified three decades later.

It travels some 275m (900ft) from Restauradores, a central city square, up to the picturesque streets of Bairro Alto. The journey takes just three minutes.

The two carriages on the Glória route are attached to opposite ends of a haulage cable which is pulled by electric motors.

As one carriage travels downhill, its weight lifts the other, allowing them to ascend and descend simultaneously, reducing the energy need.

The second, intact carriage could be seen just metres from the wreckage at the bottom of the hill.

Reuters An intact yellow and white tram stands a short distance from the mangled wreckage of another tram on a narrow, sloping city street.Reuters

How safe are Lisbon’s funicular railways?

Expressing regret for the crash, Carris said it had opened an investigation “to determine the causes of this accident”.

The company said in a statement that it had complied with “all maintenance protocols”:

  • General maintenance took place every four years and was last carried out in 2022
  • Interim repairs were made every two years, the last of which took place in 2024
  • Monthly and weekly maintenance programmes and daily inspections were also “scrupulously complied with”

“Everything was scrupulously respected,” company head Pedro Bogas said separately, adding that maintenance of the funiculars had been carried out by a contractor for the past 14 years.

“We have strict protocols, excellent professionals for many years, and we need to get to the bottom of what happened,” he added.

How have people reacted to the crash?

The country was observing a national day of mourning on Thursday while Lisbon Mayor Carlos Moedas declared three days of mourning in the capital.

Posting on X, Moedas said: “I extend my heartfelt condolences to all the families and friends of the victims. Lisbon is in mourning.”

Portuguese President Marcelo Rebelo de Sousa said he “deeply” regretted the “fatalities and serious injuries” caused by the crash.

Pedro Sánchez, prime minster of neighbouring Spain, said he was “appalled by the terrible accident”.

“All our affection and solidarity with the families of the victims and with the Portuguese people in this difficult moment,” he wrote in a statement on X.

European Commission President Ursula von der Leyen sent her “condolences to the families of the victims”.

In an interview with BBC Radio 4’s Today programme, Fabiana Pavel, who is president of a Lisbon residents’ association, said her community was shocked.

She said the funicular is an important means of public transportation for those who live in Bairro Alto, “especially for people with reduced mobility as it allows them to easily climb a steep hill”.

“At the time of the accident there may have been parents with children returning from school.”

Ms Pavel added that the cable car is used disproportionately by tourists, leaving locals unable to use the service as a means of transport “because it has become a tourist attraction”.

Flags outside the European Parliament in Brussels have been flying at half mast to mark Portugal’s day of mourning.

“The tragic accident on the Elevador da Gloria has shaken Europe deeply,” Roberta Metsola, president of the European Parliament, posted on X.

Symphonic’s Expansion in Puerto Rico: Collaborating with High Ground Music and Appointing Victor Roque as LATAM Executive

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Indie distributor and music services company Symphonic Distribution is expanding its presence in Puerto Rico through a partnership with recently-formed indie label High Ground Music (HGM) and the appointment of Victor Roque as Senior Director, A&R and Client Development for Latin America.

The partnership with HGM will combine Symphonic’s distribution platform with HGM’s “creative vision, fast-release strategy, and artist-first development model,” Symphonic said in a statement on Thursday (September 4).

HGM is led by several former execs at Rimas Entertainment, the Puerto Rico-headquartered indie label best known for representing Bad Bunny. Among those execs is Kamil Jacob “KJ” Assad, HGM’s CEO and a producer and A&R known for helping discover artists such as Eladio Carrión, Mora, and ROA, as well as award-winning songwriter Dirty.

“High Ground’s vision is speed with intention: create, release, learn, repeat,” Assad said. “With Symphonic, we have the platform and scale to deliver that vision globally, while keeping artists at the center.”

Also on HGM’s leadership team is Federico Carmona, who serves Co-CEO and Managing Partner & Creative Director. Carmona spent a decade as Senior Label Manager, A&R and Label Relations for Rimas, where he led project management and creative direction for Eladio Carrión, Jowell & Randy, Ñengo Flow, Corina Smith, Cazzu, and Kiko El Crazy, among others.

“Our goal is simple, to give artists the high ground they need to elevate and break barriers,” Carmona said. “We see potential where others don’t, we take risks where others won’t, and we keep going when others won’t.”

HGM is launching with a fresh roster of artists including Fonta, Okayyy and the visionary Colombian producer-artist CUZ, whose credits include Bad Bunny’s Velda, multiple tracks on Eladio Carrión’s latest album DON KBRN, Quevedo, Feid, and more.

“All of us at Symphonic as well as High Ground strongly believe in putting artists first,” Symphonic CEO Jorge Brea added. “We have big plans for our growth in Puerto Rico and beyond that [are] already beginning to come to fruition.”

“High Ground’s vision is speed with intention: create, release, learn, repeat.”

KJ Assad, High Ground Music

Also as part of its effort to expand its presence in Puerto Rico and the broader Caribbean region, Symphonic has appointed business development expert Victor Roque to the role of Senior Director, A&R and Client Development, LATAM.

In this role, Roque will lead Symphonic’s efforts in artist acquisition and catalog growth across the Caribbean region. He will be based in Puerto Rico and will report to Symphonic’s VP of LATAM Business Development, Greg Vinas.

Roque brings with him a decade of experience leading the marketing team and the LaMusica app for the Spanish Broadcasting System (SBS), a US-based media company specializing in Spanish-speaking audiences.

As National Director of Marketing and Special Events at SBS, he oversaw the teams responsible for radio and events promotion, experiential marketing, and business development for the digital division. He also played a key role in developing and growing the LaMusica app.

Through his company Looking Pop, Roque oversees marketing for artists including Randy Nota Loca from the iconic duo Jowell & Randy, Lenny Tavárez, Rafa Pabón, Shadow Blow, DJ John Elle, and others.

“Throughout my career, my passion has always been to connect with and showcase the incredible talent of Latin American artists,” Roque said. “Symphonic shares this passion and is constantly on the pulse of the best and brightest new talent.”

We have big plans for our growth in Puerto Rico and beyond that [are] already beginning to come to fruition.”

Jorge Brea, Symphonic

“Victor’s deep knowledge of the LATAM music ecosystem and impressive track record made him a natural fit to lead our growth efforts in the region,” Vinas added. “I look forward to welcoming the many new artists that will undoubtedly be joining the Symphonic family as a result of both of these exciting developments.”

Founded in 2006 in Tampa, Florida, by Jorge Brea, Symphonic has expanded its presence from the US to Latin America, Brazil, Canada, the Caribbean, Europe, Africa, and Asia.

Its roster of current and past artists include Imogen Heap, Tokischa, Doechii, Surf Mesa, DJ Muggs (Cypress Hill), Daddy Yankee, Nicky Jam, Ozuna, El Alfa, Juan Luis Guerra, Onyx, Pi’erre Bourne, Nick Murphy/Chet Faker, Rob Garza (Thievery Corporation), CloZee, Freddie Gibbs, and others.Music Business Worldwide

Maps and Diagrams of the Lisbon Funicular Involved in the Accident

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Source: Google Earth (background image)

The New York Times

The vintage Lisbon funicular that crashed on Wednesday, killing at least 16 people, lost control when one of its two yellow-and-white carriages hurtled into a building.

The funicular, one of Lisbon’s most popular tourist attractions, transports passengers to and from the scenic Bairro Alto neighborhood.

The funicular has two interconnected carriages powered by overhead electric cables. The carriages run in opposite directions and are attached by an underground cable system that runs through a pulley at the top of the hill.

The weight of the carriage that travels downhill helps lift the other, and they pass each other midway along the route. Each of the two vehicles on the line can carry about 40 people.

At the site of the crash, the roof of the carriage lay sideways on Thursday beside a jumble of metal pieces and broken wooden seats.

Photo by Pedro Nunes/Reuters

The New York Times

The crash happened near Restauradores Square in the center of Lisbon, Portugal’s hilly capital. The street was cordoned off, but people who gathered at the site left bunches of flowers.

Challenging the Client

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Client Challenge



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Legendary Basketball Coach George Raveling Passes Away at 88

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George Raveling, a Hall of Fame basketball coach who played a critical role in Michael Jordan signing a landmark endorsement deal with Nike, died Monday at age 88.

Raveling’s family said Tuesday in a statement that he had “faced cancer with courage and grace.”

“There are no words to fully capture what George meant to his family, friends, colleagues, former players, and assistants — and to the world,” the family statement read.

“He will be profoundly missed, yet his aura, energy, divine presence, and timeless wisdom live on in all those he touched and transformed.”

Raveling had a career record of 335-293 (.533) from 1972-94 at Washington State, Iowa, and USC. He had a losing record in his first season at each school before making multiple trips to the NCAA Tournament.

He was named NABC Coach of the Year in 1992 and Pac-10 Coach of the Year in 1976, 1983, and 1992.

In addition, Raveling became the first African American coach in the Atlantic Coast Conference (ACC) in 1969, when he was hired as the head coach at Maryland.

His success at those programs opened the door for Raveling to join the U.S. Olympic basketball staffs in 1984 and 1988. Jordan was on the 1984 team that won gold at the Olympic Games in Los Angeles.

George Raveling Convinced Michael Jordan To Sign With Nike

At the 1984 Summer Olympics in Los Angeles, Raveling persuaded Jordan to sign with Nike during a brief conversation while he served as an assistant coach for the U.S. men’s basketball team under Bobby Knight.

Raveling then introduced Jordan to Sonny Vaccaro at Nike, which helped lead to a contract that gave Jordan his own brand, made him millions of dollars, and revolutionized the athletic apparel industry.

Ben Affleck and Matt Damon also produced a 2023 film titled Air about Nike’s signing of Michael Jordan and the Air Jordan brand. Marlon Wayans played Raveling in the film.

George Raveling Michael JordanGeorge Raveling Michael Jordan

“For more than 40 years, he blessed my life with wisdom, encouragement, and friendship,” Jordan said in a statement. “He was a mentor in every sense and I’ll always carry deep gratitude for his guidance. I signed with Nike because of George, and without him, there would be no Air Jordan.”

Jordan said during a 2015 interview with Kurt Helin of USA Today that “I never wore Nike shoes until I signed with Nike” and “I was a big Adidas, Converse guy coming out of college.”

Sportico’s Kurt Badenhausen reported last year that Nike’s Jordan Brand was worth $7 billion.

Raveling Turned Basketball Into An International Game

NBA commissioner Adam Silver called Raveling “a pioneering force” who helped transform the sport of basketball into an international game.

“During his long and impactful tenure at Nike, George traveled the world — mentoring multiple generations of players and coaches promoting the sport that defined his identity,” Silver said in a statement.

“He broke barriers as a college basketball coach and was a towering voice in our industry. I valued my friendship with George and admired how he led with poise, dignity, and respect.”

Raveling also played basketball at Villanova from 1957-60, averaging 12.3 points and 14.6 rebounds over his last two seasons. The Philadelphia Warriors selected Raveling in the eighth round of the 1960 draft, but he never appeared in an NBA game.

“The finest human being, inspiring mentor, most loyal alum and a thoughtful loving friend,” Jay Wright, who coached Villanova to national championships in 2016 and 2018, posted on X.

“Coach Raveling lived his life for others, His heart was restless and kind and now rests In the lord!”

Current Villanova head coach Kevin Willard said in a statement that he has “long appreciated the enormous impact Coach has made not just on our game, but on so many of us in it. I know Villanova held a special place in his heart and we are forever grateful for his contributions to this program.”

Raveling was inducted into the Naismith Memorial Basketball Hall of Fame in 2015.