21.7 C
New York
Tuesday, September 30, 2025
Home Blog Page 164

Reports say Israel’s Netanyahu has decided on complete control of Gaza | Gaza News

0

Netanyahu’s war cabinet set to approve military operations across entire enclave, according to Israeli media.

Israeli Prime Minister Benjamin Netanyahu is set to announce plans to fully occupy the Gaza Strip, Israeli media have reported.

Netanyahu’s decision will see the Israeli military expand its operations across the entire enclave, including areas where Hamas’s captives are being held, i24NEWS, The Jerusalem Post, Channel 12 and Ynet reported on Monday.

“The decision has been made,” Amit Sega, chief political analyst with Channel 12, quoted an unnamed senior official in Netanyahu’s office as saying.

“Hamas won’t release more hostages without total surrender, and we won’t surrender. If we don’t act now, the hostages will starve to death and Gaza will remain under Hamas’s control.”

The Palestinian Ministry of Foreign Affairs condemned the reported plans and called on the international community to “intervene urgently to prevent their implementation, whether they are a form of pressure, trial balloons to gauge international reactions, or genuinely serious”.

Netanyahu’s office did not immediately respond to Al Jazeera’s request for comment.

The reports come as Netanyahu is set to convene his war cabinet on Tuesday to discuss the next steps for Israel’s military in Gaza as its war in the besieged enclave nears the two-year mark.

Netanyahu is facing growing international pressure to allow more humanitarian aid into Gaza and halt the war amid mounting Palestinian deaths due to malnutrition and Israeli attacks.

At least 74 Palestinians, including 36 aid seekers, were killed in Israeli attacks on Monday, according to medical sources in Gaza.

The Israeli leader is also facing mounting domestic pressure to secure the release of Hamas’s remaining captives in Gaza, following the release of footage of detainees Rom Braslavski and Evyatar David appearing emaciated.

Netanyahu on Monday doubled down on his war goals, including eliminating Hamas and securing the release of the remaining captives.

“We must continue to stand together and fight together to achieve all our war objectives: the defeat of the enemy, the release of our hostages, and the assurance that Gaza will no longer pose a threat to Israel,” Netanyahu said at the start of a regular cabinet meeting on Monday.

Senior Hamas official Osama Hamdan on Monday accused the United States and other Western countries of turning a blind eye to Israeli atrocities, and said that Netanyahu’s government bore “full responsibility” for the lives of the captives “due to its stubbornness, arrogance, and evasion of reaching a ceasefire agreement, and the escalation of the war of extermination and starvation against our people”.

More than 60,930 Palestinians, including at least 18,430 children, have been killed in Gaza since October 2023, according to Gaza health authorities.

Forty-nine captives, including 27 who are believed to be dead, are still being held by Hamas, according to Israeli authorities.

Assessing Team USA’s Pan Pacs Roster Post-Worlds, WUGs, and U.S. Nationals

0

By Sean Griffin on SwimSwam

Three of the five meets used to determine Team USA’s roster for next summer’s Pan Pacific Championships are officially in the books, so it’s time to take stock of where things stand.

As a reminder, the 2026 Pan Pac roster will be selected based on the top times from:

  • ‘A’ Finals at the USA Swimming 2025 National Championships
  • Finals at the 2025 World Aquatics Championships
  • Finals at the 2025 World University Games
  • Finals at the 2025 World Aquatics Junior Championships
  • ‘A’ Finals at the 2025 TYR Pro Summer Championships

Using the 2025 summer championship meets as selection for Pan Pacs marks a different approach than USA Swimming has used in the past.

In previous editions, the Pan Pac roster would be determined at the U.S. National Championships of that year, usually about two weeks earlier, and then combined results from Nationals and Pan Pacs would be used to select the World Championship team the following year.

There will still be a U.S. National Championship meet next summer prior to Pan Pacs, scheduled to run July 28-August 1 in Irvine before Pan Pacs kicks off less than two weeks later (August 12-15) at the same pool.

Pan Pac Rosters can be a maximum size of 26 men and 26 women.

When swimmers qualify for the team in any event, they become eligible to swim other events at the Pan Pacs. However, only the top two swimmers per nation can advance from prelims to the championship final. ‘B’ finals have also been held in past editions, typically allowing one swimmer per nation, except in 2018 when two per nation were permitted in that heat.

With the stroke 50s being added to the Olympic program for 2028, those events will no longer have a different selection process than the others. Previously, the non-Olympic 50-meter events were the lowest priority for selection meets.

SELECTION PRIORITIES

  • Priority #1
    • Available Swimmers who have:
      • The four fastest times in the 100-meter Freestyle and 200-meter Freestyle
      • The fastest time in each event other than the 100-meter and 200-meter Freestyles
  • Priority #2
    • Available Swimmers who have the second fastest time in each event other than the 100-meter and 200-meter Freestyles
  • Priority #3
    • Available Swimmers who have the fifth fastest times in the 100-meter Freestyle and 200-meter Freestyle
  • Priority #4
    • Available Swimmers who have the third fastest time in each event other than the 100-meter and 200-meter Freestyles
  • Priority #5
    • Available Swimmers who have the fourth fastest time in each event other than the 100-meter and 200-meter Freestyles

CURRENT EVENT-BY-EVENT RANKINGS

Notes:

  • The list below shows the top eight swimmers for each event based on the specified criteria, not the top eight fastest swimmers nationwide for each event this season.
  • The times listed below may not reflect each swimmer’s season best. Per the criteria outlined above, only times posted in ‘A’/championship finals at the designated meets are considered.
  • Relay lead-offs from finals are not allowed to be considered.
  • USA Swimming specified that only times from “Finals” at Worlds will count toward qualification, not from “Semifinals & Finals.” However, we did note if a swimmer went faster in a semifinal. The only case this affects is the men’s 200 breaststroke, where Josh Matheny posted 2:08.87 at Nationals for Priority #1, while AJ Pouch swam 2:08.34 in the Worlds semifinals before finishing 2:09.13 in the final.

Women’s 50 Freestyle:

  1. Gretchen Walsh – 23.91
  2. Torri Huske – 23.98
  3. Kate Douglass – 24.04
  4. Simone Manuel – 24.39
  5. Maxine Parker – 24.41
  6. Julia Dennis – 24.58
  7. Annam Olasewere – 24.62
  8. Cadence Vincent – 24.90

Women’s 100 Freestyle:

  1. Torri Huske – 52.43
  2. Gretchen Walsh – 52.78
  3. Simone Manuel – 52.83
  4. Kate Douglass – 53.16
  5. Erin Gemmell – 53.51
  6. Anna Moesch – 53.54
  7. Maxine Parker – 53.56
  8. Claire Weinstein – 53.72

Women’s 200 Freestyle:

  1. Claire Weinstein – 1:54.67
  2. Katie Ledecky – 1:55.26
  3. Torri Huske – 1:55.71
  4. Erin Gemmell  – 1:55.82
  5. Anna Peplowski – 1:55.82 (Note: Gemmell won the swim-off over Peplowski, meaning she will likely get the Priority 1 Pan Pacs roster spot nod)
  6. Bella Sims – 1:57.18
  7. Cavan Gormsen – 1:57.21
  8. Simone Manuel – 1:57.44

Women’s 400 Freestyle:

  1. Katie Ledecky – 3:58.49
  2. Claire Weinstein – 4:00.05
  3. Bella Sims – 4:07.11
  4. Cavan Gormsen – 4:07.64
  5. Michaela Mattes – 4:09.66
  6. Mila Nikanorov – 4:11.36
  7. Gena Jorgenson – 4:11.96
  8. Madi Mintenko – 4:12.01

Women’s 800 Freestyle:

  1. Katie Ledecky – 8:05.62
  2. Claire Weinstein – 8:19.67
  3. Jillian Cox – 8:19.88
  4. Mila Nikanorov – 8:27.61
  5. Kate Hurst – 8:32.67
  6. Gena Jorgenson – 8:33.79
  7. Katie Grimes – 8:34.15
  8. Katie McCarthy – 8:34.35

Women’s 1500 Freestyle:

  1. Katie Ledecky – 15:26.44
  2. Claire Weinstein – 16:01.96
  3. Jillian Cox – 16:05.88
  4. Kate Hurst – 16:15.40
  5. Gena Jorgenson – 16:15.44
  6. Michaela Mattes – 16:22.22
  7. Maya Geringer – 16:24.69
  8. Mila Nikanorov – 16:26.67

Women’s 50 Butterfly:

  1. Gretchen Walsh – 24.66
  2. Kate Douglass – 25.39
  3. Brady Kendall – 26.02
  4. Mena Boardman – 26.23
  5. Caroline Larsen – 26.24 (went 26.06 in World University Games semifinal)
  6. Beata Nelson – 26.32
  7. Leah Shackley – 26.38
  8. Ella Welch – 26.41

Women’s 100 Butterfly:

  1. Gretchen Walsh – 54.73
  2. Torri Huske – 56.61
  3. Alex Shackell – 57.71
  4. Charlotte Crush – 58.09
  5. Leah Shackley – 58.22
  6. Ella Welch – 58.57
  7. Beata Nelson – 58.73
  8. Tess Howley – 59.35

Women’s 200 Butterfly:

  1. Regan Smith – 2:04.99
  2. Tess Howley — 2:05.69 (went 2:05.20 in World University Games semifinal)
  3. Caroline Bricker – 2:05.80
  4. Alex Shackell – 2:07.03
  5. Lindsey Looney – 2:07.30
  6. Audrey Derivaux – 2:07.75
  7. Carli Cronk – 2:11.07
  8. Campbell Stoll – 2:11.60

Women’s 50 Backstroke:

  1. Katharine Berkoff – 26.97
  2. Regan Smith – 27.20
  3. Claire Curzan – 27.26
  4. Leah Shackley – 27.31
  5. Kennedy Noble – 27.67
  6. Isabelle Stadden – 27.78
  7. Rhyan White – 27.92
  8. Kaitlyn Owens – 28.04

Women’s 100 Backstroke:

  1. Regan Smith – 57.35
  2. Katharine Berkoff – 58.13
  3. Leah Shackley – 58.60 & Claire Curzan – 58.60 (tie)
  4. N/A
  5. Kennedy Noble – 59.78
  6. Phoebe Bacon – 58.80
  7. Charlotte Crush – 59.30
  8. Rylee Erisman – 59.39

Women’s 200 Backstroke:

  1. Regan Smith – 2:04.29
  2. Claire Curzan – 2:05.09
  3. Leah Shackley – 2:05.99
  4. Phoebe Bacon – 2:06.79
  5. Kennedy Noble – 2:07.82 (went 2:06.97 in World University Games semifinal)
  6. Rhyan White – 2:08.13
  7. Charlotte Crush – 2:08.39
  8. Teagan O’Dell – 2:08.62

Women’s 50 Breaststroke:

  1. Lilly King – 29.88 *retiring
  2. McKenzie Siroky – 30.43
  3. Emma Weber — 30.43 (Note: Siroky won the swim-off over Weber, meaning she will likely get the Priority 1 Pan Pacs roster spot nod)
  4. Skyler Smith – 30.47
  5. Alex Walsh – 30.54
  6. Piper Enge – 30.86
  7. Lucy Thomas – 31.02
  8. Rachel McAlpin – 31.34

Women’s 100 Breaststroke:

  1. Kate Douglass – 1:05.27
  2. Lilly King – 1:06.02 *retiring
  3. Alex Walsh – 1:06.50
  4. Emma Weber – 1:06.55
  5. Piper Enge – 1:07.61
  6. McKenzie Siroky – 1:07.66
  7. Gabby Rose – 1:08.54
  8. Elle Scott – 1:08.99

Women’s 200 Breaststroke:

  1. Kate Douglass – 2:18.50
  2. Alex Walsh – 2:22.45
  3. Katie Christopherson – 2:26.65
  4. Abigail Herscu – 2:26.87
  5. Leah Hayes – 2:27.68
  6. Emma Weber – 2:27.69
  7. Lucy Bell – 2:27.72
  8. Kayda Geyer – 2:29.72

Women’s 200 IM:

  1. Alex Walsh – 2:08.45
  2. Phoebe Bacon – 2:09.22
  3. Leah Hayes – 2:09.48
  4. Caroline Bricker – 2:10.12
  5. Audrey Derivaux – 2:10.91
  6. Teagan O’Dell – 2:11.25
  7. Lucy Bell – 2:12.33

Women’s 400 IM:

  1. Emma Weyant – 4:34.81
  2. Leah Hayes – 4:36.04
  3. Katie Grimes – 4:36.52
  4. Teagan O’Dell – 4:39.96
  5. Audrey Derivaux – 4:41.39
  6. Emily Brown – 4:43.38
  7. Zoe Dixon – 4:44.18
  8. Kayla Han – 4:44.49

Men’s 50 Freestyle:

  1. Jack Alexy – 21.36 (went 21.32 in Worlds semifinal)
  2. Santo Condorelli – 21.68
  3. Jonny Kulow – 21.73
  4. Quintin McCarty – 21.79
  5. Chris Guiliano – 21.86
  6. Patrick Sammon – 22.11
  7. Matt King – 22.12
  8. Daniel Baltes – 22.19

Men’s 100 Freestyle:

  1. Jack Alexy – 46.92 (went 46.81 in Worlds semifinal)
  2. Patrick Sammon – 47.47
  3. Chris Guiliano – 47.49
  4. Destin Lasco – 47.58
  5. Jonny Kulow – 47.82
  6. Shaine Casas – 47.92
  7. Henry McFadden – 47.97
  8. Grant House – 48.01

Men’s 200 Freestyle:

  1. Luke Hobson – 1:43.73
  2. Gabriel Jett – 1:44.70
  3. Rex Maurer – 1:45.13
  4. Henry McFadden – 1:45.22
  5. Carson Foster – 1:45.45
  6. Kieran Smith – 1:45.72
  7. Chris Guiliano – 1:45.73
  8. Luka Mijatovic – 1:46.39

Men’s 400 Freestyle:

  1. Rex Maurer – 3:43.33
  2. Luka Mijatovic – 3:45.71
  3. Ryan Erisman – 3:46.01
  4. David Johnston – 3:47.10
  5. Kieran Smith – 3:47.17
  6. Luke Hobson – 3:47.47
  7. Alec Enyeart – 3:48.96
  8. Joey Tepper – 3:49.72

Men’s 800 Freestyle:

  1. Bobby Finke – 7:43.13
  2. Rex Maurer – 7:49.53
  3. David Johnston – 7:49.85
  4. Ryan Erisman – 7:51.74
  5. Luka Mijatovic – 7:53.80
  6. Lance Norris – 7:55.85
  7. Aiden Hammer – 7:55.94
  8. Carson Hick – 7:56.16

Men’s 1500 Freestyle:

  1. Bobby Finke – 14:36.60
  2. David Johnston – 14:57.83
  3. Aiden Hammer – 15:05.13
  4. Carson Hick – 15:05.87
  5. Lane Norris – 15:11.46
  6. Will Mulgrew – 15:11.52
  7. Gabriel Manteufel – 15:15.08
  8. Levi Sandidge – 15:16.40

Men’s 50 Butterfly:

  1. Dare Rose – 23.06 (went 23.02 in Worlds semifinal)
  2. Michael Andrew – 23.21
  3. Shaine Casas – 23.29
  4. PJ Foy – 23.32
  5. Kamal Muhammad – 23.49
  6. Will Hayon – 23.55
  7. Thomas Heilman – 23.57
  8. Jonny Kulow – 23.75

Men’s 100 Butterfly:

  1. Shaine Casas – 50.51
  2. Thomas Heilman – 50.70
  3. Dare Rose – 51.06
  4. Luca Urlando – 51.44
  5. Trenton Julian – 51.53
  6. Kamal Muhammad – 51.89
  7. Matthew Klinge – 52.15
  8. Jack Dahlgren – 52.24

Men’s 200 Butterfly:

  1. Luca Urlando – 1:51.87
  2. Carson Foster – 1:53.70
  3. Thomas Heilman – 1:54.03
  4. Trenton Julian – 1:55.26
  5. Gabriel Jett – 1:55.37
  6. Mason Laur – 1:55.63
  7. Jack Dahlgren – 1:55.97
  8. Mitchell Schott – 1:56.47

Men’s 50 Backstroke:

  1. Quintin McCarty – 24.34
  2. Shaine Casas – 24.44
  3. Will Modglin – 24.76
  4. Jack Dolan – 24.84
  5. Grant Bochenski – 24.86
  6. Jack Wilkening – 24.88
  7. Jack Aikins – 24.91
  8. Joe Hayburn – 25.26

Men’s 100 Backstroke:

  1. Will Modglin – 52.54
  2. Daniel Diehl – 52.94
  3. Tommy Janton – 53.00
  4. Jack Aikins – 53.19
  5. Keaton Jones – 53.79
  6. Jack Wilkening – 53.87
  7. Hudson Williams – 54.25
  8. Destin Lasco – 54.27

Men’s 200 Backstroke:

  1. Jack Aikins – 1:54.25
  2. Keaton Jones – 1:54.85
  3. Daniel Diehl – 1:55.08
  4. David King – 1:55.64
  5. Michael Hochwalt – 1:57.00
  6. JT Ewing – 1:58.08
  7. Tommy Hagar – 1:58.47
  8. Caleb Maldari – 2:00.72

Men’s 50 Breaststroke:

  1. Campbell McKean – 26.90
  2. Michael Andrew – 26.92
  3. Brian Benzing – 27.40
  4. Travis Gulledge – 27.46
  5. Nate Germonprez – 27.55
  6. Alexei Avakov – 27.70
  7. Jake Wang – 27.79
  8. Ben Cono – 27.86

Men’s 100 Breaststroke:

  1. Campbell McKean – 58.96
  2. Josh Matheny – 59.18
  3. Ben Delmar — 59.80
  4. Nate Germonprez – 59.89
  5. Michael Andrew – 59.99
  6. AJ Pouch – 1:00.17
  7. Jassen Yep – 1:00.32
  8. Gabe Nunziata – 1:00.86

Men’s 200 Breaststroke:

  1. Josh Matheny – 2:08.87
  2. AJ Pouch – 2:09.31 (went 2:08.34 in Worlds semifinal)
  3. Ben Delmar – 2:09.50
  4. Gabe Nunziata – 2:09.71
  5. Josh Bey – 2:10.89
  6. Campbell McKean – 2:11.12
  7. Jassen Yep – 2:11.32
  8. Andy Dobrzanski – 2:15.48

Men’s 200 IM:

  1. Shaine Casas – 1:54.30
  2. Carson Foster – 1:55.76
  3. Trenton Julian – 1:57.59
  4. Owen McDonald – 1:57.98
  5. Grant House – 1:58.07
  6. Kieran Smith – 1:58.11
  7. Mitchell Schott – 1:59.17
  8. Baylor Nelson – 2:02.63

Men’s 400 IM:

  1. Bobby Finke – 4:07.46
  2. Carson Foster – 4:07.92
  3. Rex Maurer – 4:09.65
  4. Baylor Nelson – 4:12.69
  5. Luka Mijatovic – 4:16.75
  6. Mason Laur – 4:17.21
  7. Tommy Bried – 4:17.52
  8. Mitchell Schott – 4:21.55

THE ROSTER BREAKDOWN, AS THINGS CURRENTLY STAND

WOMEN:

Priority #1 (12 swimmers):

Priority #2 (5 swimmers):

Priority #3 (1 swimmer):

Priority #4 (9 swimmers, 1 over 26 roster limit):

Only 8 of the 9 swimmers qualified in the priority 4 sector can qualify. Per USA Swimming, the tie is broken as follows:

“Each swimmer’s fastest Time in their Event will be ranked according to the AQUA Points Table, 2025. The swimmer who has the highest ranking shall be Selected to the Team.”

  • Leah Shackley – 100 Back (3rd), 200 Back (3rd) –> 930 AQUA points
  • Jillian Cox – 800 Free & 1500 Free (3rd), 1500 Free (3rd) –> 865 (1500) / 912 (800) AQUA points
  • Caroline Bricker – 200 Fly (3rd) –> 907 AQUA points
  • Skyler Smith – 50 Breast (officially 4th, but technically 3rd due to King’s retirement) –> 876 AQUA points
  • Alex Shackell – 100 Fly (3rd) –> 874 AQUA points
  • Katie Grimes – 400 IM (3rd) –> 873 AQUA points
  • Bella Sims – 400 Free (3rd) –> 864 AQUA points
  • Brady Kendall – 50 Fly (3rd) –> 827 AQUA points
  • Katie Christopherson – 200 Breast (3rd) –> 825 AQUA points

MEN:

Priority #1 (17 swimmers):

Priority #2 (9 swimmers = MAX 26 roster limit, no priority 3, 4, & 5 swimmers):

Read the full story on SwimSwam: How Team USA’s Pan Pacs Roster Is Looking After Worlds, WUGs, and U.S. Nationals

Client Challenge: Overcoming Obstacles and Achieving Success

0



Client Challenge



JavaScript is disabled in your browser.

Please enable JavaScript to proceed.

A required part of this site couldn’t load. This may be due to a browser
extension, network issues, or browser settings. Please check your
connection, disable any ad blockers, or try using a different browser.

Scientists Utilize Cancer Technique to Safeguard Diabetes Cells

0

Borrowing a cancer cell’s disguise, scientists shielded insulin-producing cells from attack by the immune system, a breakthrough that could pave the way for targeted type 1 diabetes treatments without whole-body immunosuppression.

There has been a lot of research into understanding how cancer evades the body’s immune system, and the ways that science might be able to get around that. One of the ways cancer hides itself in the body is by attaching sugar molecules to the surface of its cells.

Now, a group of researchers from the Mayo Clinic has applied that knowledge, and the sneaky immune-system-avoiding trick used by cancer, to develop a treatment for type 1 diabetes.

“Our findings show that it’s possible to engineer beta cells that do not prompt an immune response,” said Virginia Shapiro, PhD, an immunology researcher and the study’s corresponding author.

ST8Sia6 is an enzyme, a type of protein, whose job is to attach special sugar molecules called sialic acids to the surface of cells. It works inside the cells’ “packaging” area, the Golgi apparatus, before proteins reach the cell surface. By adding sialic acids, ST8Sia6 changes how cells look to the immune system. These sugars act like tags or shields that send a “don’t attack me!” signal to certain immune cells. The immune cells that read this shield use special receptors called sialic acid-binding immunoglobulin-type lectins, Siglecs that, when they bind to these sugars, usually tell the immune system to calm down and not launch an attack.

In healthy tissues, this process helps prevent unnecessary immune damage. However, some cancers produce more ST8Sia6 than normal, which increases the “don’t attack me!” signals on the cancer cell surface. Immune cells, such as T cells, bind to these extra sugars through the Siglec receptors, which sends an “off” signal. As a result, the immune system ignores or tolerates the cancer cells instead of killing them.

A cluster of insulin-producing beta cells (green) under attack by a dense cluster of immune cells (blue dots) in a preclinical model of type 1 diabetes

Mayo Clinic

“The expression of this enzyme basically ‘sugar coats’ cancer cells and can help protect an abnormal cell from a normal immune response,” Shapiro said. “We wondered if the same enzyme might also protect a normal cell from an abnormal immune response.”

In type 1 diabetes (T1D), the immune system mistakenly thinks the insulin-producing beta cells in the pancreas are dangerous, so it sends immune cells to attack and destroy them. Once the beta cells are gone, the body can’t make insulin, and blood sugar control is lost.

The researchers used non-obese diabetic (NOD) mice, a well-established model for human T1D, and genetically modified them to express ST8Sia6 specifically in pancreatic beta cells. The expression could be turned on or off using the antibiotic doxycycline, which allowed for time-specific testing. They monitored diabetes onset via blood glucose levels, microscopically analyzed the animals’ beta cells, profiled the immune cells, and measured inflammation and antibody levels.

Only 6% of genetically modified female NOD mice developed diabetes, compared to 60% of control mice – a 90% reduction in disease incidence. Male mice were also protected, though less dramatically, likely due to natural sex differences in the mouse models. The researchers observed that in genetically modified mice, beta cells were preserved into old age (300 days), while in control mice, they were largely destroyed.

Despite having normal levels of autoantibodies and autoreactive T cells – indicative of an autoimmune response – the genetically modified mice didn’t experience progressive insulitis, which is when the immune cells infiltrate the pancreas islets, clusters of cells in which beta cells are located. Immune protection conferred by ST8Sia6 was restricted to the islets; other organs still showed signs of autoimmunity.

“Though the beta cells were spared, the immune system remained intact,” said lead author Justin Choe, a Mayo Clinic MD-PhD program student, studying at the Graduate School of Biomedical Sciences and the Alix School of Medicine. “We found that the enzyme specifically generated tolerance against autoimmune rejection of the beta cell, providing local and quite specific protection against type 1 diabetes.”

This research offers a potential breakthrough in treating or even preventing type 1 diabetes
This research offers a potential breakthrough in treating or even preventing type 1 diabetes

The immune protection seen by the researchers came from modifying the local immune environment, not from removing autoreactive immune cells entirely. The enzyme specifically reduced pro-inflammatory cells and the production of IL-12p35, a cytokine or chemical messenger that’s crucial for promoting inflammation. Additionally, it altered the balance in the islets towards regulatory T cells (Tregs), which suppress inflammation. Switching off ST8Sia6 expression at 20 weeks still preserved the protection, suggesting that early intervention was sufficient to induce long-lasting immune tolerance.

There are some limitations to the study. Primarily, the NOD mouse model doesn’t perfectly replicate human T1D, especially due to differences like the female-biased disease progression that isn’t seen in humans. And effects seen in mouse immune systems may not directly apply to humans. Also, while the immune protection was strong in the pancreatic islets, other autoimmune manifestations continued, which highlights the specificity of the protection but also potential gaps. And, the study didn’t fully evaluate long-term immune suppression risks, although no major systemic suppression was observed.

Putting aside these limitations, though, this research offers a potential breakthrough in treating or even preventing T1D via localized immune system modulation. It could also boost the success of pancreatic islet cell transplantation by protecting transplanted cells from immune attack without suppressing the immune system across the entire body.

“A goal would be to provide transplantable cells without the need for immunosuppression,” said Shapiro. “Though we’re still in the early stages, this study may be one step toward improving care.”

The study was published in The Journal of Clinical Investigation.

Source: Mayo Clinic

Former Brazilian President placed under house arrest by judge

0

Brazil’s Supreme Court has ordered that the former right-wing President Jair Bolsonaro be put under house arrest.

He is standing trial over allegations he plotted a coup, which he denies.

The judge in charge of investigating Bolsonaro, Alexandre de Moraes, said the decision was because Bolsonaro hadn’t complied with restraining orders put on him last month.

In response to the order, Bolsonaro’s legal team denied breaching any restraining order and said they would appeal the ruling, according to Reuters news agency.

In a statement on X, the US state department said it “condemns” the court order and “will hold accountable all those aiding and abetting sanctioned conduct”.

Donald Trump has used Bolsonaro’s trial, which he calls a “witch-hunt”, as a justification for imposing 50% tariffs on some Brazilian goods despite the US having a trade surplus with Brazil.

Mr Moraes, who the US has also sanctioned, said Bolsonaro had used the social networks of his allies including his sons to spread messages that encouraged attacks on the Supreme Court and foreign intervention in the Brazilian judiciary.

On Sunday, pro-Bolsonaro rallies were held in various Brazilian cities. One of his sons, Flávio, who is a senator, briefly put his father on speakerphone to the crowd in Rio de Janeiro.

Flávio also reportedly later published a video, which he deleted afterwards, of his father on the other side of the call sending a message to supporters.

Mr Moraes cited the incident in his ruling, saying Bolsonaro “deliberately flouted” previous restrictions, according to local media.

“The flagrant disregard for the preventative measures was so obvious that – it bears repeating – the defendant’s own son, senator Flávio Nantes Bolsonaro, decided to delete the post from his Instagram account in order to conceal the legal transgression,” the ruling said.

Mr Moraes also banned Bolsonaro from receiving visits, except from lawyers or people authorised by the Supreme Court, and from using a mobile phone directly or through third parties.

“Justice is blind, but it is not foolish,” wrote Mr Moraes, adding that the court “will not allow a defendant to make a fool of it, thinking that he will go unpunished because he has political and economic power”.

These restrictions were imposed because of allegations he was encouraging Donald Trump to interfere in the case.

Trump and Bolsonaro enjoyed a friendly relationship when their presidencies overlapped, with the pair meeting at the White House in 2019.

In a social media post last month, Trump voiced his support for the former president saying Bolsonaro “was not guilty of anything” and praised him as a “strong leader” who “truly loved his country”.

Governor of Texas orders the arrest of absent Democrats during Monday’s redistricting vote.

0

Texas governor orders arrest of Democrats absent at Monday redistricting vote

Russia-Ukraine Conflict: Recap of Major Events on Day 1,258 | Latest Updates on Russia-Ukraine War

0

Here are the key events on day 1,258 of Russia’s war on Ukraine.

Here is how things stand on Tuesday, August 5:

Fighting

  • Three people were killed in a Russian attack on the Stepnohirsk community in Ukraine’s Zaporizhia region, the local military administration said on Telegram. Russia launched 405 attacks on 10 settlements in the region in the past day, the administration said on Monday.
  • Russian drone attacks killed three people in the Chuhuiv district of Ukraine’s Kharkiv region, the regional prosecutor’s office said. The victims included a man killed when Russian drones caused a fire in his home in the village of Losivka, and a man and a woman who were riding a motorcycle when they were killed. The prosecutor’s office said it was investigating the motorcycle attack as a possible war crime.
  • Russian attacks across Ukraine’s Kherson region killed one person and damaged homes, cars and a gas pipeline, Governor Oleksandr Prokudin said. A man who was injured by artillery shelling on the town of Beryslav on July 27 also passed away due to his injuries, Prokudin added.
  • Russian attacks killed one person in Dobropillya city in the Pokrovsky region and another person in Kostiantynivka city, in Ukraine’s Donetsk region, Donetsk Governor Vadym Filashkin said.
  • Ukraine’s Security Service (SBU) claimed that Ukrainian drones hit five Russian fighter jets at Saky airfield in Russian-occupied Crimea, destroying one of them.
  • Ukrainian President Volodymyr Zelenskyy said that mercenaries from China, Tajikistan, Uzbekistan, Pakistan and African countries are fighting with Russian forces in the Vovchansk area of Kharkiv in northeastern Ukraine.
  • Ukraine’s general staff acknowledged that it was responsible for a drone attack that caused a fire at a fuel depot of Sochi airport in southern Russia on Sunday.

Military aid

  • The Netherlands will contribute 500 million euros ($578m) to buy US military equipment for Ukraine, including Patriot air defence system parts and missiles. The purchase will make the Netherlands the first country to participate in a new scheme where NATO countries fund US weapons to send to Kyiv.

Sanctions

  • India’s Ministry of External Affairs spokesperson Randhir Jaiswal said in a statement that the United States and European Union’s “targeting” of the nation for importing oil from Russia after Moscow’s full-scale invasion of Ukraine was “unjustified and unreasonable”.
  • Stephen Miller, deputy chief of staff at the White House, said earlier on Fox News: “What he [US President Donald Trump] said very clearly is that it is not acceptable for India to continue financing this war by purchasing the oil from Russia.”
  • Trump said he would “substantially” increase tariffs on India for what he said was the buying and reselling of “massive amounts” of Russian oil “for big profits”.

Ceasefire talks

  • Trump said his special envoy, Steve Witkoff, would again visit Russia to continue talks on its war in Ukraine.

Politics and diplomacy

  • Russian Former President Dmitry Medvedev said that Moscow’s abandonment of a moratorium on medium- and short-range nuclear missiles was “the result of NATO countries’ anti-Russian policy”, in a post on X.
  • The trial has begun in the March 22, 2024, shooting attack in a Moscow concert hall that killed 149 people. Russian President Vladimir Putin has claimed, without providing evidence, that Ukraine was involved in the attack, an allegation Kyiv vehemently denies.

Corruption

  • Ukraine’s National Anti-Corruption Bureau said in a statement that it had charged six people, including a lawmaker and a government official, involved in “systematically misappropriat[ing] funds allocated by local authorities for defence needs”, including funds meant for the purchase of drones and jamming equipment for the military.

Following Figma’s successful IPO, investors are eyeing these companies for their upcoming IPOs

0

Figma’s sensational IPO last week resurrected longstanding debates about IPO pricing and first day pops—an unsurprising reaction to the newly listed stock’s 333% surge in its first days of trading. As investors dissect the offering (and as Figma’s stock settles back a bit, falling 27% on Monday), other key questions have emerged: Will Figma’s debut entice other startups to jump into the fray, bringing an end to the tech industry’s IPO drought? And if so, who’s next?

There’s a long list of late-stage VC-backed tech companies with strong customer bases that Wall Street investment bankers would love to take public. Many of these multi-billion dollar companies, including Databricks, Klarna, Stripe, and SpaceX, have been subjects of IPO speculation for years. And then of course, there’s the crop of richly valued AI startups, from OpenAI and Anthropic, to Elon Musk’s xAI. 

Those companies will likely continue to be in the spotlight, but in conversations I had with several investors following Figma’s debut, other names came up as more likely to IPO sooner including Canva, Revolut, Midjourney, Motive, and Anduril. 

“Having positive IPOs is a good signal for everybody,” says Kirsten Green, founder and managing partner at Forerunner Ventures, whose portfolio company Chime recently went public and experienced a 37% pop in stock price on its first day of trading. (Forerunner also has investments in public company Hims & Hers and late stage private companies including Oura.) “I believe we should revisit this idea: an IPO is the Series A of being in the public market–and having that really be a motivator to people’s willingness, and maybe even eagerness to go public.”  (As if on cue, HeartFlow, a medical technology company, filed an S-1 for its IPO at a $1.3 billion valuation on August 1).

Kyle Stanford, the director of research on US venture capital at PitchBook, notes that just 18 venture-backed companies have gone public through June 30 of this year. This, he says, is a factor of policy uncertainties that translate to funding headwinds as well as the overfunding that occurred in 2021 that continues to stymie venture capital. “Figma hopefully starts to break the dam, but it’s been a pretty slow quarter,” he says.

Though Figma, which makes design software, is profitable and has a strong set of integrated AI capabilities, these qualities are not essential to companies bound for IPO success, says Stanford. He says that investors would prefer companies to generate a minimum of $200 million in revenue that grows at high rates and prioritize positive free cash flow over profitability. Having an AI story is also “very important,” unless the company is very high growth and profitable by wide margins. 

Canva may be a most-compelling case since it’s a design company with similar fundamentals to that of Figma, said multiple investors I interviewed. Design collaboration company Canva has raised about $589 million over 18 rounds at a $32 billion valuation, higher than that of Figma’s at the time of its IPO. “Canva is a big winner when it comes to what happened yesterday with Figma,” says Jason Shuman, an investor at Primary Ventures. Shuman, who is not an investor in Canva, points to Canva’s $3 billion annual revenue and 35% year-over-year growth as signs of its business’ durability.

Others agree. “Canva—after looking at Figma, holy crap—they’re going to try to IPO as soon as possible,” says Felix Wang, Managing Director and Partner at Hedgeye Risk Management, who is not a Canva investor.  Canva, which was recently valued at $37 billion during a share buy back, did not respond to Fortune’s request for comment.

Wang and others note that the surge in Figma’s price is, in many ways, not actually driven by Figma. Rather, the market is at an all-time high, causing retail trader demand for companies new to market. “They don’t even know this company, but they know it’s a new company,” says Wang of retail traders investing in Figma. “They’re going to put some money into it, and then, more interestingly: they’re going to show it off on social media.”

As Figma is to Canva; NuBank is to Revolut, reasons Primary’s Shuman. He looks at fintech NuBank, which is up around 13% from its early 2025 IPO and thinks that Revolut, which has a very similar business model, could copycat. Revolut told Fortune in a statement: “our focus is not on if or when we IPO, but on continuing to expand the business, building new products, and providing better and cheaper services to serve our growing global customer base.” 

Another potential IPO candidate in the near-future is chipmaker Cerebras, says Primary’s Shuman, who invests in vertical AI, B2B, SMB and finance and defense companies but has no stake in Cerebras or Revolut. (Cerebras filed an S-1 in September 2024 but its IPO was delayed by regulators concerned about a $335 million investment by UAE-based G42. Now, it’s been cleared by regulators for a public market listing, but the company has held off on an IPO as it fundraises $1 billion, reports The Information.)

Many companies, including the largest and hottest private company OpenAI (which just nabbed a $300 billion valuation, per the New York Times), have significant incentives to remain private. This is because they can avoid public scrutiny that arises from disclosures required of public companies and have access to significant private capital for liquidity infusions that are often essential. 

Yet, the fact that behemoths like OpenAI, Stripe ($91 billion valuation) and SpaceX ($400 billion valuation) are private may even be a hidden cost for the public market. “I’m going to get philosophical,” says Forerunner’s Green. “Part of the public market was created so the broader population could participate in the economy and in the growth of the economy; it wasn’t meant to sit in a few people’s hands.”

One behemoth may be entering the stock market limelight. Anduril, the defense tech company that nabbed a $30.5 billion valuation on its Series G, has incentives to remain private due to the nature of its business. But Pitchbook’s Stanford predicts it to be the next tech IPO. In addition to Anduril’s CEO announcing it will “definitely” become publicly traded, its value proposition is core to Trump Administration priorities in security and defense, which could make it a hot pick for investors, Stanford reasons. 

“Other than that,” he says the list of potential IPO candidates these days is long: “There’s probably about 300 other companies that it could be.”

The Korean survivors of the Hiroshima bomb are visited by the BBC

0

Hyojung Kim

BBC Korean in Hapcheon

BBC/Hyojung Kim An old woman white short white hair and wire frame glasses sits in a chair and looks into the cameraBBC/Hyojung Kim

Lee Jung-soon, 88, is one of many nuclear bomb survivors who now lives in Hapcheon, South Korea

At 08:15 on August 6, 1945, as a nuclear bomb was falling like a stone through the skies over Hiroshima, Lee Jung-soon was on her way to elementary school.

The now-88-year-old waves her hands as if trying to push the memory away.

“My father was about to leave for work, but he suddenly came running back and told us to evacuate immediately,” she recalls. “They say the streets were filled with the dead – but I was so shocked all I remember is crying. I just cried and cried.”

Victims’ bodies “melted away so only their eyes were visible”, Ms Lee says, as a blast equivalent to 15,000 tons of TNT enveloped a city of 420,000 people. What remained in the aftermath were corpses too mangled to be identified.

“The atomic bomb… it’s such a terrifying weapon.”

It’s been 80 years since the United States detonated ‘Little Boy’, humanity’s first-ever atomic bomb, over the centre of Hiroshima, instantly killing some 70,000 people. Tens of thousands more would die in the coming months from radiation sickness, burns and dehydration.

The devastation wrought by the bombings of Hiroshima and Nagasaki – which brought a decisive end to both World War Two and Japanese imperial rule across large swaths of Asia – has been well-documented over the past eight decades.

Less well-known is the fact that about 20% of the immediate victims were Koreans.

Korea had been a Japanese colony for 35 years when the bomb was dropped. An estimated 140,000 Koreans were living in Hiroshima at the time – many having moved there due to forced labour mobilisation, or to survive under colonial exploitation.

Those who survived the atom bomb, along with their descendants, continue to live in the long shadow of that day – wrestling with disfigurement, pain, and a decades-long fight for justice that remains unresolved.

Getty Images A person walks up a street towards a pair of blocky white buildings in front of a brown hillside, with trees growing on the side of the roadGetty Images

Hapcheon has been dubbed “Korea’s Hiroshima” due to the number of nuclear bomb survivors who lived there after the war

“No-one takes responsibility,” says Shim Jin-tae, an 83-year-old survivor. “Not the country that dropped the bomb. Not the country that failed to protect us. America never apologised. Japan pretends not to know. Korea is no better. They just pass the blame – and we’re left alone.”

Mr Shim now lives in Hapcheon, South Korea: a small county which, having become the home of dozens of survivors like he and Ms Lee, has been dubbed “Korea’s Hiroshima”.

For Ms Lee, the shock of that day has not faded – it etched itself into her body as illness. She now lives with skin cancer, Parkinson’s disease, and angina, a condition stemming from poor blood flow to the heart, which typically manifests as chest pain.

But what weighs more heavily is that the pain didn’t stop with her. Her son Ho-chang, who supports her, was diagnosed with kidney failure and is undergoing dialysis while awaiting a transplant.

“I believe it’s due to radiation exposure, but who can prove it?” Ho-chang Lee says. “It’s hard to verify scientifically – you’d need genetic testing, which is exhausting and expensive.

The Ministry of Health and Welfare (MOHW) told the BBC that it had gathered genetic data between 2020 and 2024 and would continue further studies until 2029. It would “consider expanding the definition of victims” to second- and- third-generation survivors only “if the results are statistically significant”, it said.

The Korean toll

Of the 140,000 Koreans in Hiroshima at the time of the bombing, many were from Hapcheon.

Surrounded by mountains with little farmland, it was a difficult place to live. Crops were seized by the Japanese occupiers, droughts ravaged the land, and thousands of people left the rural country for Japan during the war. Some were forcibly conscripted; others were lured by the promise that “you could eat three meals a day and send your kids to school.”

But in Japan, Koreans were second-class citizens – often given the hardest, dirtiest and most dangerous jobs. Mr Shim says his father worked in a munitions factory as a forced labourer, while his mother hammered nails into wooden ammunition crates.

In the aftermath of the bomb, this distribution of labour translated into dangerous and often fatal work for Koreans in Hiroshima.

BBC/Hyojung Kim An old man in a chequered blazer sits in front of a black-and-white photograph showing destroyed streets and debris BBC/Hyojung Kim

For Shim Jin-tae, it’s not just about being compensated – it’s about being acknowledged

“Korean workers had to clean up the dead,” Mr Shim, who is the director of the Hapcheon branch of the Korean Atomic Bomb Victims Association, tells BBC Korean. “At first they used stretchers, but there were too many bodies. Eventually, they used dustpans to gather corpses and burned them in schoolyards.”

“It was mostly Koreans who did this. Most of the post-war clean-up and munitions work was done by us.”

According to a study by the Gyeonggi Welfare Foundation, some survivors were forced to clear rubble and recover bodies. While Japanese evacuees fled to relatives, Koreans without local ties remained in the city, exposed to the radioactive fallout – and with limited access to medical care.

A combination of these conditions – poor treatment, hazardous work and structural discrimination – all contributed to a disproportionately high death toll among Koreans.

According to the Korean Atomic Bomb Victims Association, the Korean fatality rate was 57.1%, compared to the overall rate of about 33.7%.

About 70,000 Koreans were exposed to the bomb. By year’s end, some 40,000 had died.

Outcasts at home

After the bombings, which led to Japan’s surrender and Korea’s subsequent liberation, about 23,000 Korean survivors returned home. But they were not welcomed. Branded as disfigured or cursed, they faced prejudice even in their homeland.

“Hapcheon already had a leper colony,” Mr Shim explains. “And because of that image, people thought the bomb survivors had skin diseases too.”

Such stigma made survivors stay silent about their plight, he adds, suggesting that “survival came before pride”.

Ms Lee says she saw this “with her own eyes”.

“People who were badly burned or extremely poor were treated terribly,” she recalls. “In our village, some people had their backs and faces so badly scarred that only their eyes were visible. They were rejected from marriage and shunned.”

With stigma came poverty, and hardship. Then came illnesses with no clear cause: skin diseases, heart conditions, kidney failure, cancer. The symptoms were everywhere – but no-one could explain them.

Over time, the focus shifted to the second and third generations.

BBC/Hyojung Kim A middle-aged woman with short black hair and glasses looks into the cameraBBC/Hyojung Kim

Second-generation survivor Han Jeong-sun can’t walk without dragging herself, and has faced stigma from her own family

Han Jeong-sun, a second-generation survivor, suffers from avascular necrosis in her hips, and can’t walk without dragging herself. Her first son was born with cerebral palsy.

“My son has never walked a single step in his life,” she says. “And my in-laws treated me horribly. They said, ‘You gave birth to a crippled child and you’re crippled too—are you here to ruin our family?’

“That time was absolute hell.”

For decades, not even the Korean government took active interest in its own victims, as a war with the North and economic struggles were treated as higher priorities.

It wasn’t until 2019 – more than 70 years after the bombing – that MOHW released its first fact-finding report. That survey was mostly based on questionnaires.

In response to BBC inquiries, the ministry explained that prior to 2019, “There was no legal basis for funding or official investigations”.

But two separate studies had found that second-generation victims were more vulnerable to illness. One, from 2005, showed that second-generation victims were far more likely than the general population to suffer depression, heart disease and anaemia, while another from 2013 found their disability registration rate was nearly double the national average.

Against this backdrop, Ms Han is incredulous that authorities keep asking for proof to recognise her and her son as victims of Hiroshima.

“My illness is the proof. My son’s disability is the proof. This pain passes down generations, and it’s visible,” she says. “But they won’t recognise it. So what are we supposed to do – just die without ever being acknowledged?”

Peace without apology

It was only last month, on July 12, that Hiroshima officials visited Hapcheon for the first time to lay flowers at a memorial. While former PM Hatoyama Yukio and other private figures had come before, this was the first official visit by current Japanese officials.

“Now in 2025 Japan talks about peace. But peace without apology is meaningless,” says Junko Ichiba, a long-time Japanese peace activist who has spent most of her life advocating for Korean Hiroshima victims.

She points out, the visiting officials gave no mention or apology for how Japan treated Korean people before and during World War Two.

BBC/Hyojung Kim A man stands at a temple in front of rows of small rectangular wooden planks, standing vertically, with Chinese characters on themBBC/Hyojung Kim

A memorial hall in Hapcheon holds 1,160 wooden tablets – each one bearing the name of a Korean killed by the nuclear bomb

Although multiple former Japanese leaders have offered their apologies and remorse, many South Koreans regard these sentiments as insincere or insufficient without formal acknowledgement.

Ms Ichiba notes that Japanese textbooks still omit the history of Korea’s colonial past – as well as its atomic bomb victims – saying that “this invisibility only deepens the injustice”.

This adds to what many view as a broader lack of accountability for Japan’s colonial legacy.

Heo Jeong-gu, director of the Red Cross’s support division, said, “These issues… must be addressed while survivors are still alive. For the second and third generations, we must gather evidence and testimonies before it’s too late.”

For survivors like Mr Shim it’s not just about being compensated – it’s about being acknowledged.

“Memory matters more than compensation,” he says. “Our bodies remember what we went through… If we forget, it’ll happen again. And someday, there’ll be no one left to tell the story.”

Rafael Ricardo Jiménez-Dan discusses Rimas, independence, and music publishing

0

To most of the music world, Rafael Ricardo Jiménez-Dan remains an enigma.

Despite founding Rimas in 2014 – the company behind global superstar Bad Bunny and one of the most influential forces in Latin music – he has never publicly discussed his journey, his vision, or the controversial job he once held in Venezuelan politics.

That changes today.

Speaking from his home in Florida, the wealthy Venezuelan entrepreneur is finally ready to tell his story. It’s a tale of risk-taking, family sacrifice, and the relentless pursuit of a dream that would ultimately reshape the Latin music landscape.

Yet, according to Jiménez-Dan, it’s also a story that has been distorted by inaccurate media speculation, legal filings, and political opportunism.

The catalyst for our conversation was MBW’s recent coverage of the independent music revolution, which referenced various media reports about Rimas’s origins.

Jiménez-Dan is particularly keen to clear up details of his history working in the government of Hugo Chávez.

This association has been whipped up not only by media reports but also by one particular headline-chasing politician in Puerto Rico, who used it as the basis for her suggestion that Rimas and/or Bad Bunny could somehow politically corrupt the minds of PR’s citizens.

“Every single dollar that I invested in music is the result of entrepreneurship, working hard with my family and friends, taking risks that others wouldn’t take,” says Jiménez-Dan, strongly refuting the rumor that his startup funds for Rimas were accumulated during his time in government.

Jiménez-Dan, who says he worked for the Chávez government for just one year (2006-2007), adds: “I am not and never have been a political actor. I’m not a member of any political party in Venezuela – not left, not right. I never had any involvement in the coup d’état with Chávez.”

Jiménez-Dan confirms that in 2023, he sold his 60% stake in Rimas’ label and talent management firm – Rimas Entertainment – to a third party, though contractual restrictions prevent him from revealing the buyer’s identity. (MBW sources are adamant it was Sony Music/The Orchard, in a deal that eventually led to Noah Assad, alongside Bad Bunny, taking majority control of the company.)

However, Jiménez-Dan continues to own 60% of Rimas Publishing, an independent publishing company, where he sees exciting opportunities ahead. (Rimas Publishing, led by Emilio Morales as Managing Director, is home to three subsidiary publishers – RSM, Risama, and Megasongs – and counts on its roster talent such as Bad Bunny, Eladio Carrión, Subelo NEO, and Mora.)

“You founded Music Business Worldwide in 2015, and I founded Rimas in 2014,” says Jiménez-Dan. “You can understand how hard it is to fight everyone who doesn’t believe in you.

“So I feel that for the first time, with you, I can explain how Rimas was born…”


There’s not a whole lot about the origins of Rimas online, aside from a couple of Spanish language pieces and two articles IN BILLBOARD, which informed my recent column. Where in your view has some of the reporting strayed from the path?

The history of Rimas is one of the most amazing, incredible histories about entrepreneurship, and fortunately, it has a very happy ending. Unfortunately, there has been a lot of misunderstanding, and I have never found the right channel to speak about that.

During our negotiations [with Rimas Entertainment’s majority-buyer in 2023], out of the blue, some journalists from Billboard approached me with a very tough and hostile line [of questioning]. I didn’t feel comfortable doing an interview, so all my words were transmitted through my lawyers in LA.

Despite offering them documents with very hard facts, the result was what I had expected from the very beginning — a very slanted focus in the reporting.


One persistent story is that you made a $2 million startup investment in Rimas when it launched in 2014, and largely let others run the company.

This is one of the worst [mistruths] that people tell about Rimas. It originates from a trial involving my former business associate and his ex-partner, and the media [picked it up from there]. She put in the legal documents some stories she had heard [about Jiménez-Dan’s initial level of investment]. This is the only source of this information; it is totally false.

I never gave anyone else a check for $2 million, or even a small amount of money, to create Rimas. I used my credit cards; I mortgaged one property that I had in Florida. I paid for hundreds of lunches with radio promoters and video producers. I was there with my kid Ricardo, going to Best Buy and the hardware store to buy things to fix up the recording studios.

“Launching and building Rimas was a lot of effort. This idea of me being this guy who bought in a suitcase with $2 million, and gave it to someone – this is totally false.”

I abandoned my family for weeks, waiting up until sunrise in recording studios for one of the first Rimas artists to sign an agreement with us.

Launching and building Rimas was a lot of effort. This idea of me being this guy who bought in a suitcase with $2 million, and gave it to someone – this is totally false.

I was the only shareholder of Rimas from 2014 to 2018. I was the 100% owner for four years.


Is it true that Rimas is an acronym for your children’s names?

Absolutely. The name is a word game: “Rimas” means “rhymes” in Spanish, but it’s also an acronym of the names of my three kids: Ricardo, Marianna, and Sophya. Almost all my ventures have, in some way, the names of my family. This is what moves me – my family – and they are involved in all my projects.

In 2014, I was managing artists in Venezuela, and they wanted to make music in Puerto Rico. We started visiting studios in San Juan, and I saw a land of opportunities, but a [local music] industry that was in a very bad moment. If you remember, 2014 was the worst year in the music industry from the 1980s to today, with very low revenue.

The major labels dominated the industry, and the format was changing — CDs were sunsetting, and streaming was starting.

We found this space in San Juan and saw an opportunity [to invest in creating recording facilities and a record label]. I couldn’t find a recording studio with worldwide quality [in the region] to do something amazing.


When did Noah Assad enter the picture?

I have great respect and appreciation for Noah. I’m thankful for all the things we built together with the rest of the team.

Noah was an employee of my company even before we created Rimas. He was hired as a manager of one of the artists I managed at that time.

I was involved in hospitality, food, and other industries through my holding company, Risamar Business Group. I needed help, and I saw in Noah a person with talent who was also connected in Puerto Rico. When I met him, he was organizing some local parties and working with a couple of producers who worked with one of our artists.

“I have great respect and appreciation for Noah… I offered him 40% of the shares in the company… I have no regrets about that.”

When Rimas was created, Noah continued to be an employee — a good one.

Four years later, I offered him 40% of the shares in the company, with the commitment that I needed him more involved in day-to-day operations. It’s natural for founders to take the next step and give people opportunities. I have no regrets about that.


Noah became absolutely central to Bad Bunny’s development and success.

Almost from the beginning, Noah was very close with Benito. He is the key manager in his career – this is undeniable.

I have nothing but respect and appreciation for him and his family, and for his talent in handling the artistic side.

One suggestion in BILLBOARD’S REPORTING was that you never actually met Bad Bunny. Is that true?

No, it’s totally false. I met Benito while we were in Puerto Rico. I was very private and reserved, but Puerto Rico is 100 by 35 miles – it’s a small island.

Probably in 2016, we were at an event in Mayagüez with [artists] Jowell and Randy, and other artists who were in the company at that time. Eladio Carrión was with us there too.

“I remember Eladio being invited to sing at a very tiny bar, and he said, ‘This is my friend Benito.’”

I remember Eladio being invited to sing at a very tiny bar, and he said, “This is my friend Benito.” Benito started singing Diles, one of the first songs he released. When we saw that spark in Benito and the reaction of the people, we saw that this was going to be great.

During several occasions, I was alongside [Bad Bunny] at music events, Billboard conferences, even helping him with personal things.

But I have a philosophy: executives in the music industry sometimes feel the right to control every single aspect of an artist. This independent venture took a different approach – artistic freedom was key in the development of Rimas.


By 2017, Rimas was attracting serious attention from major players. What made you decide to stay independent at that time?

In 2017, many companies approached us. Atlantic Records started working with us, reviewing our financial documents, and we were involved in negotiations with Interscope/Universal in Los Angeles too. I had to fly there – my team, including Noah, was the face of those negotiations.

The same thing happened with Scooter Braun.

Scooter was discussing with us the potential acquisition of the company. At that time, he was working with Ariana Grande and Justin Bieber, and had a powerful presence in LA.

I thought we were ready to take the next step, but ultimately we decided to maintain our independence.


What specifically made you turn down those offers in 2017?

We had built something special with our philosophy of artistic freedom.

At that time, the major labels, even with all their resources, still wanted to control every single aspect of the artist – how they dress, what producers they work with, the creative direction.

“We weren’t ready to give up our freedom, even for the resources these companies could offer.”

We were independent and really trying to do something out of the box. I’m not the guy making pictures [of myself] or paying for billboards; I think the real ‘power players’ are the artists and the creative spirit in them. The creative process had to be protected from the borders that the majors put on artists.

By 2017, we had proven that this approach could work, so why change it? We weren’t ready to give up that freedom, even for the resources those companies could offer.


So what changed by 2023 that made you decide to sell your stake in Rimas Entertainment?

I have contractual restrictions about what I can say, but I can confirm that I sold my 60% share to a third party [in 2023]. It was time for the company to move to the next step.

I believe in the whole professional staff and what we had built during all these years; it wasn’t only one artist, it was agreements with many artists, catalog, procedures, staff, and a reputation and network.

2023 was a great year after the pandemic. Music was steadily growing, especially Latin music. I saw the opportunity, not only for me and my family after years of working very hard, but also for the company to get moved to a level that I probably couldn’t achieve alone, because others have more resources and capacity.


Are you happy with the idea of Noah now being in control of the company?

Totally, absolutely. I’m happy for several reasons.

For one thing, I still control 60% of Rimas Publishing, which excites me the most because of the authorship side of the business.

I used to say I didn’t want to be on the billboards or at the Grammys – I love to enjoy [the music business] from the sofa in my house with my wife and kids when some of the artists in the company are recognized with a prize.

It’s the same thing with this. I love Rimas being more and more successful. Every single new achievement of Rimas is a reason for me to be happy and thankful.

The DNA, the name of my kids, will always be in the company.


Rimas’s partnership with The Orchard has been crucial to Bad Bunny’s global success. You chose to go with their services model rather than a traditional major label deal; that was quite trailblazing at the time.

When streaming started, there was no more room for opacity in the music business. The numbers are the numbers. I’m a guy from technology – I come from systems engineering – and I said, “This is the new landscape. You can’t hide the truth anymore.”

At that time, the music industry was full of opacity. Transparency was a rare commodity. I saw it when fighting to find a place for a song on the radio or fighting to discuss an agreement with a label company — a lack of transparency, hidden costs, hidden things. Everything was ‘in the dark’.

I feel Rimas is part of a movement that is changing music forever. The [availability of] backbone services – like distribution and technology – could open the way for new players, independent players, that could change the landscape of how the music industry operates.


The Orchard has done a great job with Rimas and Bad Bunny globally. That partnership has shown what’s possible when you combine independent entrepreneurship with major-level infrastructure.

Yes, and it proved that efficiency and hard work matter more than the tricks. It’s opening a lot of doors for new opportunities for other [labels] and artists.


I need to address the political controversy surrounding your background. A Puerto Rican politician tried to link your history with Hugo Chávez’s government to Bad Bunny and his influence on the Puerto Rican people. Can you set the record straight?

For about one year from 2006 to 2007, I served as Vice Minister of Legal Certainty in my country, Venezuela.

I was a lawyer and a technician, with ideas to improve institutions. I have no regrets. I worked for a year trying to improve access to justice and transparency – the same things we’re fighting for now in music – and strengthen the rule of law.

I became very frustrated. I realized [the system] was impossible to change from within, and I resigned from my position. I was never in an administrative or economic position handling money. I was in institutional management on the technical side of government.

“I am not and never have been a political actor.”

Every single dollar that I invested in music is the result of entrepreneurship, working hard with my family and friends, taking risks that others wouldn’t take.

I am not and never have been a political actor. I’m not a member of any political party in Venezuela – not left, not right. I was never involved in the coup d’état with Chávez.

[Editor’s note: Hugo Chávez served as President of Venezuela from 1999 through to his death in 2013 – the longest-serving national President in the history of the Americas. Despite being elected three times, he is widely seen as having consolidated power by weakening checks and balances on the executive.]

The people around me – my family, friends, the people related to me through the businesses I’ve built – know who I am and where we come from.


Billboard reported that ‘friction’ exists between you and Noah today. How would you characterize your relationship with him?

After you build something as great as we did, you can have space for great things like appreciation, respect, and thankfulness, while not always needing to agree on everything. The thing is how you find elevated, civilized ways to discuss and find common ground.

Of course, we can have a couple of disagreements, but the company is working very well.

We [conduct ourselves] through the procedures that the operating agreements establish. If we require a meeting, we have a meeting.


Let’s finish on a positive note: Rimas Publishing. You seem very excited about this. Why are you betting on the publishing side of the business?

Rimas Publishing is a jewel. It has built a great reputation. I’m very proud of the highly professional and ethical team we have in place.

Integrity, transparency, and innovation are the pillars of Rimas Publishing today. The team is writing one of the most beautiful pages in music publishing history.

Since 2023, we’ve grown from 90 to 160 artists, and counting.


What excites you about the future of music publishing specifically?

The availability of information and data is changing the industry. Transparency will rule, and there will be no room for the hidden tricks of the past.

In an industry with a lack of transparency, when you find someone to tell you the truth, show you the numbers, when you can discuss openly the agreement size and revenue side – it’s like a domino effect.

“Benito and Latin music has opened the possibility of the unknown.”

That’s what’s happened with Benito and Latin music – it has opened the possibility of the unknown.

Tomorrow, there will be a guy from Mozambique, Guinea, or New Zealand who uses an instrument, creates melodies, and delivers a punch line… his music could be global within two hours.

I’m happy to have been part of this journey, but at least on the [songwriter] side, I want to be part of the music that is happening now.


Any final thoughts on the Rimas legacy?

Rimas represents everything Puerto Rico can achieve. Since I left Venezuela, Puerto Rico has become very important to me. It’s where I developed one of my most important businesses, where Rimas grew, and where I found purpose.

If I went back 10 years, I probably would have done the same thing.

My kids’ DNA will always be in the company, and I’m thankful for that journey. I’m proud of it.Music Business Worldwide